Li CS, Sinha R. Inhibitory control and emotional stress regulation: neuroimaging evidence for frontal-limbic dysfunction in psycho-stimulant addiction. Neurosci Biobehav Rev 32: 581-597

Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center S103, New Haven, CT 06519, USA.
Neuroscience & Biobehavioral Reviews (Impact Factor: 8.8). 02/2008; 32(3):581-97. DOI: 10.1016/j.neubiorev.2007.10.003
Source: PubMed


This review focuses on neuroimaging studies that examined stress processing and regulation and cognitive inhibitory control in patients with psycho-stimulant addiction. We provide an overview of these studies, summarizing converging evidence and discrepancies as they occur in the literature. We also adopt an analytic perspective and dissect these psychological processes into their sub-components, to identify the neural pathways specific to each component process and those that are more specifically involved in psycho-stimulant addiction. To this aim we refer frequently to studies conducted in healthy individuals. Despite the separate treatment of stress/affect regulation, stress-related craving or compulsive drug seeking, and inhibitory control, neural underpinnings of these processes overlap significantly. In particular, the ventromedial prefrontal regions including the anterior cingulate cortex, amygdala and the striatum are implicated in psychostimulant dependence. Our overarching thesis is that prefrontal activity ensures intact emotional stress regulation and inhibitory control. Altered prefrontal activity along with heightened striatal responses to addicted drug and drug-related salient stimuli perpetuates habitual drug seeking. Further studies that examine the functional relationships of these neural systems will likely provide the key to understanding the mechanisms underlying compulsive drug use behaviors in psycho-stimulant dependence.

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Available from: Chiang-shan Ray Li, Oct 04, 2015
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    • "Certainly, clarification is needed as to which subfacets of impulsivity are most relevant to food addiction as well as insight into the potential association between emotion regulation and food addiction. Emotion regulation also likely plays a part in food addiction as it does in drug use disorders (Aldao, Nolen-Hoeksema, & Schweizer, 2010; Fox, Hong, & Sinha, 2008; Li & Sinha, 2008). Emotion regulation is the extent to which individuals influence, experience and express their emotions (Hofmann, Sawyer, Fang, & Asnaani, 2012). "
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    ABSTRACT: Food addiction is the clinical occurrence in which individuals develop physical and psychological dependencies on high fat, high sugar, and highly palatable foods. Past research has demonstrated a number of similarities between food addiction and drug use disorders including the activation of specific brain regions and neurotransmitters, disrupted neuronal circuitry, and behavioral indicators of addiction such as continued use despite negative consequences. The present study examined the role of impulsivity and emotion dysregulation in food addiction as both play salient roles in drug use disorders. Poisson regression analyses using data from 878 undergraduate students revealed negative urgency, the tendency to act impulsively when under distress, and emotion dysregulation positively predicted symptom count on the Yale Food Addiction Scale (Gearhardt, Corbin, & Brownell, 2009) whereas a lack of premeditation negatively predicted symptom count (all ps<0.05). Future research is needed to confirm precursors to eating episodes in food addiction, elucidate causal mechanisms, and support an explanatory model of food addiction. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Eating behaviors 07/2015; 19. DOI:10.1016/j.eatbeh.2015.06.007
    • "Prominent biological theories of addiction implicate the brain reward system: the genes, neurotransmitters, transporters, and enzyme targets of the dopamine, serotonin, and glutamate systems of the brain (C.-S. R. Li & Sinha, 2008; Nestler, 2005; Schnoll, Johnson, & Lerman, 2007). The most recent studies include genomewide association studies and meta-analyses of genomewide association studies (Bierut et al., 2007; GENEVA Consortium, 2012; C.-Y. Li et al., 2011; Thorgeirsson et al., 2010), which have implicated a number of genes in predisposition to addiction , as well as difficulty remaining abstinent. "
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    Journal of Health Communication 03/2015; 20(5):1-11. DOI:10.1080/10810730.2014.999895 · 1.61 Impact Factor
    • "Please cite this article in press as: Helena J.V. Rutherford, Norah S. Wallace, Heidemarie K. Laurent, Linda C. Mayes, Emotion regulation in parenthood, Developmental Review (2015), doi: 10.1016/j.dr.2014.12.008 person to relate to difficult or distressing emotions from a wider perspective, increasing understanding of the emotion without the need to hold onto or struggle with it (Bishop et al., 2004). With this understanding, one can avoid dysregulation related to unproductive strategies such as self-blame and rumination, and adopt more advantageous strategies (Desrosiers, Vine, Klemanski, & Nolen-Hoeksema, 2013; Shapiro, Oman, Thoresen, Plante, & Flinders, 2008). Cultivated over time, it appears that mindfulness evolves from a top–down control strategy to a bottom–up mode of emotion regulation (Chiesa, Serretti, & Jakobsen, 2012). "
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