Article

Trichodermatides A-D, novel polyketides from the marine-derived fungus Trichoderma reesei.

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Organic Letters (impact factor: 5.86). 03/2008; 10(3):393-6. DOI:10.1021/ol702674f pp.393-6
Source: PubMed

ABSTRACT Four new polyketide derivatives, Trichodermatides A-D (1-4) were isolated from the marine-derived fungus Trichoderma reesei. Trichodermatide A (1) is an unprecedented example of a polyketide with a ketal-containing pentacyclic skeleton. The chemical structures and absolute configurations of compounds 1-4 were elucidated by extensive spectroscopic methods, especially 2D NMR and CD spectral analysis, and supported by their proposed biosynthesis pathway. The cytotoxicity of 1-4 was evaluated against A375-S2 human melanoma cell line.

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Keywords

A375-S2 human melanoma cell line
 
chemical structures
 
cytotoxicity
 
extensive spectroscopic methods
 
marine-derived fungus Trichoderma reesei
 
proposed biosynthesis pathway
 
Trichodermatide
 
Trichodermatides A-D
 
unprecedented example