Article

High association of human papillomavirus infection with oral cancer: A case-control study

Universidad Autónoma Metropolitana, Mexico, D.F., Mexico.
Archives of Medical Research (Impact Factor: 2.41). 03/2008; 39(2):189-97. DOI: 10.1016/j.arcmed.2007.08.003
Source: PubMed

ABSTRACT The aim of the present study was to determine the association of high-risk human papillomavirus (HR-HPV) in Mexican individuals with oral squamous cell carcinoma (OSCC) and their association with various risk factors.
We designed a matched case-control study. Cases were individuals with newly diagnosed OSCC, age- and sex-matched with controls (1:4). Demographic and clinical data were obtained; also a self-administered questionnaire about sexual behavior was included. DNA from oral brushing was purified to amplify HPV-DNA through MY09/MY11 and GP5+/GP6+ primers and subsequently subjected to sequencing. Conditional regression models were built to calculate odds ratios (ORs) and 95% confidence intervals (CI).
Sixty two cases and 248 controls (53.2% males), median age 62 years (Q1-Q3=54-72 years) were included. HPV prevalence was 43.5% in cases and 17.3% in controls (HR-HPV: 37.1% cases, 9.7% controls). The most frequent types in cases were HPV-16 and HPV-18 (55.6 and 18.5%). The presence of HR-HPV was associated with OSCC (OR=6.2; 95% CI: 2.98-12.97) controlling for the most common risk factors. An interaction between smoking and drinking was detected, and family history of cancer was also significant (OR: 3.61; 95% CI=1.44-8.99). Early age at first sexual intercourse and large number of lifetime sexual partners showed an association with HR-HPV (p=0.019 and p=0.033, respectively).
Oral HR-HPV was strongly associated with OSCC, suggesting that HPV-16 and -18 are risk factors for oral cancer in Mexican patients. A significant association of tobacco and alcohol was confirmed. In addition, family history of cancer was associated with OSCC. The results underline the role of HPV in OSCC and its multifactorial etiology.

1 Follower
 · 
146 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The oropharyngeal squamous cell carcinomas (OPSCC) are a molecular and clinically heterogeneous group of cancer, not yet fully characterized. The most important risk factors for OPSCC are tobacco and alcohol, however, in the last fifteen years, HPV-positive OPSCC are apparently growing, principally in young male people. It is highly probable that these cases represent a new and particular OPSCC subgroup. A reclassification of OPSCC based in part on the participation of high risk human papillomavirus (HPV) as an etiological factor is likely to be proposed. In addition to the association with HPV, other biomarkers have been added to better understand the OPSCC biological behavior and response to oncologic treatment, including TP53 genotypes or changes in chromosome stability. Of particular interest is the tumor suppressor p16INK4, as its expression levels can function as a surrogate biomarker in the diagnosis of HPV-positive OPSCC. p16INK4 overexpression in combination with the demonstration of HPV active infection, according to most authors may predict a good prognosis, thus p16INK4 has been proposed (and patented) as a therapeutic target in those cancers overexpressing it. This review discusses the recent patents focusing on the p16INK4 diagnostic and prognostic value as well as its possible therapeutic activity.
    01/2014; 4(2).
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Resumen E L CÁNCER DE LA VÍAS AERODIGESTIVAS superiores (CVADS) representa la sexta ma-lignidad más común, con una incidencia anual aproximada de 400.000 personas en el mundo. Aunque los principales factores de riesgo para el CVADS siguen siendo la exposición al tabaco y alcohol, el virus del papiloma humano (VPH) recientemente se ha encontra-do asociado en la etiología del 20 al 25 % de los CVADS, principalmente los ubicados en la bucofaringe. En huma-nos el VPH es causa de cáncer por expresar dos oncopro-teínas virales: E6 y E7. Los estudios han demostrado que E6 y E7 se unen directamente a varias proteínas del hos-pedero, como p53 y pRb, para contribuir a la inestabilidad genética. El tipo de VPH de alto riesgo más asociado con cáncer de las vías aerodigestivas superiores es VPH-16. La positividad a VPH de alto riesgo se asocia a una expresión disminuida de los genes p53 y pRb, la sobreexpresión de p16 y la disminución de la expresión de EGFR, y un patrón de expresión genética diferente respecto a los pacientes con CVADS negativo a VPH de alto riesgo, esto conduce a la conclusión de que se trata de una entidad clínica distinta. Además de las diferencias etiológicos, los cánceres VPH-positivos son clínicamente diferentes en comparación con los cánceres de VPH negativos en relación con la respuesta al tratamiento y la supervivencia, siendo la positividad a VPH un biomarcador pronóstico favorable.. Abstract Upper aero-digestive tract cancer (UADTC) is the sixth most common cancer with an annual incidence of approximately 400,000 worldwide. Although the principal risk factors for UADTC remain tobacco and alcohol use, human papillomavirus (HPV) has recently been found to be etiologically associated with 20 to 25% of UADTC, mostly in the oropharynx. HPV causes human cancers by expressing two viral onco-proteins, E6 and E7. Studies have shown that E6 and E7 can directly bind to multiple host proteins as p53 and pRb, further contributing to genetic instability. The most common high risk-HPV associated with upper aero-digestive tract cancer is HPV-16. High risk-HPV positiv-ity is associated with decreased expression of the p53 and Rb genes, overexpression of p16, decreased expression of EGFR, and a different genetic expression pattern compared with patients with high risk-HPV-negative UADTC, leading to the conclusion that this is a distinct clini-cal entity. In addition to the etiological differences, HPV-positive cancers are clinically distinct when compared with HPV-negative cancers with regard to treatment response and survival outcome, with tumor HPV-positivity being a favorable prognostic biomarker.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The number of cases of oral cancer has increased in the past decade and 15 million new cases are expected by 2020 worldwide. In Mexico, oral squamous cell carcinoma is the most common malignancy type and its incidence is between 1% and 5% of total cancers, so it is very important to be aware of predisposing factors, lifestyle, habits and associated systemic diseases that affect the presence of this pathology. The complete medical history has an important role in early diagnosis of high risk patients. In Mexico the lack of updated information on risk factors, early diagnosis techniques and the little awareness of the population on preventive measures generate a big challenge in health professionals, trying to decrease the incidence of this neoplasm. The present article will provide updated concepts of the etiology of oral squamous cell carcinoma, the prevalence and incidence in Mexico, focusing on preventive measures and proper examination techniques for early diagnosis.
    Salud i Ciencia 09/2014; 20(6):636-642. · 0.02 Impact Factor

Full-text

Download
39 Downloads
Available from
Jul 23, 2014