Bilateral Paget disease of the male nipple: First report

General Surgery Department, Ankara Ataturk Teaching and Research Hospital, Askaabat Cad. Eser Sitesi B3 Blok Daire:11, Bahcelievler, Ankara 06480, Turkey.
The Breast (Impact Factor: 2.38). 07/2008; 17(3):317-8. DOI: 10.1016/j.breast.2007.11.007
Source: PubMed


Bilateral breast carcinoma is reported to occur in 5-10% of all patients with breast cancer. Paget disease of the breast represents 1-3% of all breast malignancies [Ashikari R, Park K, Huvos AG, Urban JA. Paget's disease of the breast. Cancer 1970;26:680-5; Marshall JK, Griffith KA, Haffty BG, Solin LJ, Vicini FA, McCormick B, et al. Conservative management of Paget disease of the breast with radiotherapy. Cancer 2003;97:2142-9]. However, synchronous bilateral Paget disease of the nipple is extremely rare. We report synchronous bilateral Paget disease with infiltrative ductal carcinoma in a 74-year-old man who underwent bilateral mastectomy.

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    • "Portugal Fernandes et al. 1990/[3] Female ? Greece Markopoulos et al. 1997/[19] 53/female R: LCIS of the nipple, DCIS + microinvasive ductal carcinoma L: LCIS of the nipple, DCIS USA Sahoo et al. 2002/[4] 73/female R: high-grade intraductal carcinoma L: micropapillary invasive carcinoma Italy Franceschini et al. 2005/[12] 74/male R: infiltrative ductal carcinoma Turkey Ucar et al. 2008/[6] 45/female None China Xie et al. 2012/[10] 72/female R: low-grade DCIS L—intermediate DCIS, invasive ductal carcinoma Germany Barth 2014 "
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    ABSTRACT: Paget's disease of the breast is often misdiagnosed. We report on a 72-year old patient with a history of 2.5 years without any malignant findings, followed by the identification of a bilateral Paget's disease with bilateral breast cancers. This case underlines how important histological examinations even in unusual clinical pictures are.
    03/2014; 2014(2):152836. DOI:10.1155/2014/152836
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    • "Paget's disease may present concomitantly with an underlying invasive carcinoma, ductal carcinoma in situ or with no underlying breast cancer. Forty six percent of Paget's cases present without a mass and of these, underlying invasive breast cancer is usually found in only 38% with ductal carcinoma in situ being found in the majority [4,5]. "
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    ABSTRACT: Paget's disease is an eczematous skin change of the nipple that is usually associated with an underlying breast malignancy. Male breast cancer represents only 1-3% of all breast malignancies and Paget's disease remains very rare. We present the case of a 67-year-old Caucasian man with lymphomatoid papulosis who was diagnosed with Paget's disease of the nipple and who was treated successfully with surgery alone. We discuss the presentation, investigations, management and pathogenesis of Paget's disease of the nipple. The case highlights the need to be vigilant when new skin lesions arise in the context of an underlying chronic skin disorder.
    Journal of Medical Case Reports 01/2011; 5:43. DOI:10.1186/1752-1947-5-43
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    ABSTRACT: Vorgestellt wird eine 71-jährige Patientin mit ekzematösen, therapierefraktären Hautveränderungen beider Mamillae seit 2,5 Jahren. Trotz intensiver gynäkologisch/radiologischer Abklärung konnten keine Auffälligkeiten festgestellt werden. Durch die operative Versorgung des beidseits durch Biopsie diagnostizierten M. Paget wurden jedoch duktale Karzinome (DCIS) bestätigt. Insbesondere bei therapierefraktären Hautbefunden der Mamille sollte die Indikation zur Biopsie großzügig gestellt werden. Bestätigt sich die Verdachtsdiagnose M. Paget, ist die operative Versorgung auch zum Ausschluss ursächlicher duktaler Karzinome unverzichtbar.
    Der Gynäkologe 02/2013; 46(2). DOI:10.1007/s00129-012-3115-5
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