Article

Clearance of HCV RNA following acute hepatitis A superinfection

Department of Internal Medicine and Medical Specialties, Via Passo Gravina 187, I-95127 Catania, Italy.
Digestive and Liver Disease (Impact Factor: 2.89). 02/2008; 41(5):371-4. DOI: 10.1016/j.dld.2007.11.015
Source: PubMed

ABSTRACT A transient reduction of hepatitis C virus replication during the course of acute hepatitis A virus infection has already been reported in the literature. The present study reports the case study of a subject with chronic hepatitis due to hepatitis C virus who went on to develop an acute hepatitis A. From the early onset of acute disease, hepatitis C virus ribonucleic acid became undetectable. Following recovery from acute hepatitis, alanine amino-transferase levels became persistently normal and liver biopsy revealed a reduction in the Knodell histological activity index score. Hepatitis C virus ribonucleic acid clearance was maintained up to 4 years after the onset of acute hepatitis A. During the course of the acute disease, a sharp increase in interferon gamma levels was detected in serum and in the supernatant of both unstimulated and phytoemagglutinin/lipopolysaccharide-stimulated peripheral blood mononuclear cells. Interferon gamma levels were still high 3 months later. We hypothesize that acute hepatitis A virus superinfection during the course of chronic hepatitis C may lead to hepatitis C virus ribonucleic acid clearance through an immunological mechanism related to interferon gamma production.

0 Followers
 · 
85 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Recent experimental results on normal conducting RF structures indicate that the scaling of the gradient limit with frequency is less favourable than was believed. We therefore reconsider the optimum choice of RF frequency and iris aperture for a normal conducting, two-beam linear collider with E<sub>CMS</sub>=3 TeV, a loaded accelerating gradient of 150 MV/m and a luminosity of 8ยท10<sup>34</sup>cm<sup>-2</sup>s<sup>-1</sup>. The optimisation criterion is minimizing RF costs for investment and operation with constraints put on peak surface electric fields and pulsed heating of accelerating structures. Analytical models are employed where applicable, while interpolation of simulation program results is used for the calculation of luminosity and RF structure properties.
    Particle Accelerator Conference, 2003. PAC 2003. Proceedings of the; 06/2003
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The anti-inflammatory and antiapoptotic heme degrading enzyme heme oxygenase-1 (HO-1) has been shown recently to interfere with replication of hepatitis C virus (HCV). We investigated the effect of HO-1 products carbon monoxide (CO), iron and biliverdin on HCV replication using the replicon cell lines Huh-5-15 and LucUbiNeo-ET, stably expressing HCV proteins NS3 through NS5B. Incubation of these cell lines in the presence of the CO donor methylene chloride transiently reduced HCV replication, whereas an increase of iron in cell culture by administration of FeCl(3) or iron-saturated lactoferrin did not interfere with HCV replication. Likewise, depletion of iron by deferoxamine during induction of HO-1 by cobalt-protoporphyrin IX did not restore HCV replication. The most prominent effect was observed after incubation of replicon cell lines in the presence of biliverdin. Biliverdin seems to interfere with HCV replication-mediated oxidative stress by inducing expression of antiviral interferons, such as interferon alpha2 and alpha17. CONCLUSION: The antioxidant biliverdin reduces HCV replication in vitro by triggering the antiviral interferon response and might improve HCV therapy in the future.
    Hepatology 02/2010; 51(2):398-404. DOI:10.1002/hep.23339 · 11.19 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Chronic hepatitis C (CHC) is variably prevalent around the world and is usually a blood-borne infection. Most patients will have subclinical infection at the onset, but patients who develop acute hepatitis can spontaneously clear the virus upon immune activation. Up to 80% of CHC patients will progress to chronic infection. CHC is unlikely to clear spontaneously. This article describes two female patients with transfusion-acquired CHC diagnosed by both positive hepatitis C virus (HCV)-Ab and hepatitis C virus-polymerase chain reaction (HCV-PCR) tests. Both patients cleared the infection spontaneously after more than 5 and 25years of CHC infection, respectively.
    Arab Journal of Gastroenterology 03/2011; 12(1):51-3. DOI:10.1016/j.ajg.2011.01.010