Article
In vivo visualization of abdominal malignancies with acoustic radiation force elastography.
Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Physics in Medicine and Biology (impact factor:
2.83).
02/2008;
53(1):279-93.
DOI:10.1088/0031-9155/53/1/020
pp.279-93
Source: PubMed
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Citations (0)
- Cited In (5)
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Article: Imaging and Imaging-Guided Interventions in the Diagnosis and Management of Hepatocellular Carcinoma (HCC)-Review of Evidence.
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ABSTRACT: The imaging of hepatocellular carcinoma (HCC) is challenging and plays a crucial role in the diagnosis and staging of the disease. A variety of imaging modalities, such as ultrasound, computed tomography (CT), magnetic resonance imaging (MRI) and nuclear medicine are currently used in evaluating patients with HCC. Although the best option for the treatment of these cases is hepatic resection or transplantation, only 20% of HCCs are surgically treatable. In those patients who are not eligible for surgical treatment, interventional therapies such as transcatheter arterial chemoembolization (TACE), percutaneous ethanol injection (PEI), radio-frequency ablation (RFA), percutaneous microwave coagulation therapy (PMC), laser ablation or cryoablation, and acetic acid injection are indicated. In this paper, we aimed to review the evidence regarding imaging modalities and therapeutic interventions of HCC.Iranian Journal of Radiology 11/2012; 9(4):167-77. · 0.05 Impact Factor -
Article: DYNAMIC OPTICAL COHERENCE ELASTOGRAPHY: A REVIEW.
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ABSTRACT: With the development of optical coherence tomography, the application optical coherence elastography (OCE) has gained more and more attention in biomechanics for its unique features including micron-scale resolution, real-time processing, and non-invasive imaging. In this review, one group of OCE techniques, namely dynamic OCE, are introduced and discussed including external dynamic OCE mapping and imaging of ex vivo breast tumor, external dynamic OCE measurement of in vivo human skin, and internal dynamic OCE including acoustomotive OCE and magnetomotive OCE. These techniques overcame some of the major drawbacks of traditional static OCE, and broadened the OCE application fields. Driven by scientific needs to engineer new quantitative methods that utilize the high micron-scale resolution achievable with optics, results of biomechanical properties were obtained from biological tissues. The results suggest potential diagnostic and therapeutic clinical applications. Results from these studies also help our understanding of the relationship between biomechanical variations and functional tissue changes in biological systems.Journal of innovative optical health sciences. 10/2010; 3(4):221-233. -
Article: Acoustic radiation force impulse elastography in distinguishing hepatic haemangiomata from metastases: preliminary observations.
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ABSTRACT: The increasing quality of diagnostic ultrasound has resulted in the detection of greater numbers of potentially benign hepatic lesions. Current radiological practice requires contrast enhanced ultrasound, CT or MRI to confirm the diagnosis. Acoustic radiation force impulse (ARFI) elastography is an imaging technique measuring the elasticity of biological tissues. Recent technical advances in ultrasound have made it possible to generate shear waves, whose velocity in the liver is proportional to the degree of hepatic elasticity. This shear wave velocity (SWV) may be used as a marker for both focal and diffuse liver pathology.We used this technique to examine patients with normal livers and those with haemangiomata and metastases. Patients with normal ultrasound examinations and normal liver enzymes, n = 99, had SWVs of 1.24 ± 0.23 m s(-1) (mean ± standard deviation) independent of site of measurement, age or gender. Results of SWV measurements in haemangiomata, n = 35, produced values of the same order, 1.35 ± 0.48 m s(-1). In contrast, patients with metastases, n = 10, had SWVs of 4.23 ± 0.59 m s(-1). With a cut-off value of 2.5 m s(-1), the sensitivity and specificity for haemangiomata were 97.1% and 100%, respectively, with an area under the curve of 0.999. ARFI elastography with SWV measurements is a promising new technique which could replace invasive investigations for benign hepatic lesions.The British journal of radiology 03/2011; 84(1006):939-43. · 2.11 Impact Factor
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Keywords
12 tumors
acoustic radiation force impulse
ARFI image contrast
ARFI images
ARFI method
B-mode contrast
boundary definition
Displacement contrast
echo contrast
hepatocellular carcinomas
imaging tissue elasticity
masses
mean contrast
nine patients
real-time visualization
regional cirrhotic liver parenchyma
regional non-cirrhotic liver parenchyma
renal mass
sonography/ARFI imaging
suspicious masses
