Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica.

Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Journal of Ethnopharmacology (Impact Factor: 2.94). 04/2008; 116(2):325-32. DOI: 10.1016/j.jep.2007.11.038
Source: PubMed

ABSTRACT AIMS OF THIS STUDY: Centella asiatica has a reputation to restore decline cognitive function in traditional medicine and in animal model. However, little evidence regarding the efficacy of Centella asiatica from systematized trials is available. Therefore, the present randomized, placebo-controlled, double-blind study investigated the effect of Centella asiatica on cognitive function of healthy elderly volunteer.
Twenty-eight healthy elderly participants received the plant extract at various doses ranging 250, 500 and 750 mg once daily for 2 months. Cognitive performance was assessed using the computerized test battery and event-related potential whereas mood was assessed using Bond-Lader visual analogue scales prior to the trial and after single, 1 and 2 months after treatment.
The results showed that the high dose of the plant extract enhanced working memory and increased N100 component amplitude of event-related potential. Improvements of self-rated mood were also found following the Centella asiatica treatment.
Therefore, the present findings suggest the potential of Centella asiatica to attenuate the age-related decline in cognitive function and mood disorder in the healthy elderly. However, the precise mechanism(s) underlying these effects still require further investigation.

  • [Show abstract] [Hide abstract]
    ABSTRACT: The purpose of this study was to compare working memory, saliva cortisol hormone, and problem solving skill between students in two different contexts: Open Inquiry and Conventional Learning. The participants were consisted of two classes of 86 10th grade students, from one school during the 2011 academic year. A pretest posttest control group design was used in the experiment. The tools were consisted of) salivary cortisol assay) The computerized assessment battery test) problem solving skill test. The collected data were analyzed by arithmetic mean, sd., t test, and Hotelling T-2. The findings revealed that: after intervention 1) student's saliva cortisol hormone in Open Inquiry group was lower than Conventional group at .05 level of significance 2) student's working memory in Open Inquiry group were higher than students in Conventional group at .05 level of significance, but unable to proof about the difference of student's problem solving ability. (C) 2012 Published by Elsevier Ltd. Selection and/or peer review under responsibility of Prof. Dr. Huseyin Uzunboylu
    Procedia - Social and Behavioral Sciences 12/2012; 46:5387-5391. DOI:10.1016/j.sbspro.2012.06.444
  • [Show abstract] [Hide abstract]
    ABSTRACT: Background: We previously showed that a water extract of the medicinal plant Centella asiatica (CAW) attenuates amyloid-β (Aβ)-induced cognitive deficits in vivo, and prevents Aβ-induced cytotoxicity in vitro. Yet the neuroprotective mechanism of CAW is unknown. Objective: The goal of this study was to identify biochemical pathways altered by CAW using in vitro models of Aβ toxicity. Methods: The effects of CAW on aberrations in antioxidant response, calcium homeostasis, and mitochondrial function induced by Aβ were evaluated in MC65 and SH-SY5Y neuroblastoma cells. Results: CAW decreased intracellular reactive oxygen species and calcium levels elevated in response to Aβ, and induced the expression of antioxidant response genes in both cell lines. In SH-SY5Y cells, CAW increased basal and maximal oxygen consumption without altering spare capacity, and attenuated Aβ-induced decreases in mitochondrial respiration. CAW also prevented Aβ-induced decreases in ATP and induced the expression of mitochondrial genes and proteins in both cell types. Caffeoylquinic acids from CAW were shown to have a similar effect on antioxidant and mitochondrial gene expression in neuroblastoma cells. Primary rat hippocampal neurons treated with CAW also showed an increase in mitochondrial and antioxidant gene expression. Conclusions: These data suggest an effect of CAW on mitochondrial biogenesis, which in conjunction with activation of antioxidant response genes and normalizing calcium homeostasis, likely contributes to its neuroprotective action against Aβ toxicity.
    Journal of Alzheimer's disease: JAD 01/2015; DOI:10.3233/JAD-142217 · 3.61 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Neuroprotection is a broad term commonly used to refer therapeutic strategies that can prevent, delay or even reverse neuronal damage. Herbal medicines are widely used across the globe as economical, effective and safer alternative remedies. North-East (NE) India harbours a large number of medicinal plants, it falls under Indo-Burma global hotspot one of the 34 global biodiversity hotspots. In traditional practice of medicines, people here uses a variety of medicinal plants for the treatment of various ailments. The purpose of this manuscript is to review the plants with neuroprotective potential from NE India and to provide the reference for future study of new and alternative remedies for the treatment of neurological ailments.
    International Journal of Pharmacy and Pharmaceutical Sciences 01/2015; 7(3):28-39. · 1.59 Impact Factor