Human leukocyte antigen polymorphism in chronic and aggressive periodontitis among Caucasians: A meta-analysis

Department of Operative Dentistry, Periodontology and Preventive Dentistry, University Hospital (RWTH), Aachen, Germany.
Journal Of Clinical Periodontology (Impact Factor: 4.01). 04/2008; 35(3):183-92. DOI: 10.1111/j.1600-051X.2007.01189.x
Source: PubMed


Multiple studies have reported associations between periodontitis and particular human leukocyte antigens (HLA). Because associations are inconsistent, we conducted a systematic literature review and a meta-analysis focusing on Caucasian case-control studies.
A literature search reporting on the distribution of HLA class I and II phenotypes in Caucasian patients with chronic periodontitis (CP) and aggressive periodontitis (AP) was performed. Data sources included electronic databases and bibliographies of published articles. Screening and data abstraction were conducted independently by different reviewers.
Out of 174 publications, 12 studies were considered to be suitable for meta-analysis. In patients with CP, no significant HLA associations were found. Patients with AP showed a positive association with HLA-A9 [odds ratio=2.59 (95% confidence interval 1.36-4.83), p=0.004] and HLA-B15 [1.90 (1.15-3.16), p=0.01] as well as a negative association with HLA-A2 [0.72 (0.56-0.94), p=0.01] and -B5 [0.49 (0.30-0.79), p=0.004]. On grouping all patients into one periodontitis group (AP+CP), the same deviations were confirmed with higher statistical significance. For HLA-A9 and -B15, significant heterogeneity was found between the studies. No significant associations were found with HLA class II antigens.
HLA-A9 and -B15 seem to represent susceptibility factors for AP whereas HLA-A2 and -B5 are potential protective factors against periodontitis among Caucasians.

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Available from: Jamal M. Stein, Sep 07, 2014
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    • "Thus, our results indicate a protective role of HLA-A * 02. A2 could yield an efficient antimicrobial T-cell response reducing the disease [25]. Otherwise, HLA-B * 40 was more frequent in both groups representing a risk effect against CP, although significance was also lost after Bonferroni correction. "
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    ABSTRACT: Human leukocyte antigens (HLA) have a pivotal role in immune response and may be involved in antigen recognition of periodontal pathogens. However, the associations of HLA with chronic periodontitis (CP) have not been previously studied in the Brazilian population. In an attempt to clarify the issue of genetic predisposition to CP, we examined the distribution of HLA alleles, genotypes, and haplotypes in patients from Southern Brazil. One hundred and eight CP patients and 151 healthy and unrelated controls with age-, gender-, and ethnicity-matched were HLA investigated by polymerase chain reaction with sequence specific oligonucleotides. To exclude smoking as a predisposing factor, statistical analyses were performed in the total sample and in nonsmoking individuals. The significant results showed a positive association of the A * 02/HLA-B * 40 haplotype with CP (total samples: 4.2% versus 0%, = 0.03; nonsmokers: 4.3% versus 0%, = 0.23) and a lower frequency of HLA-B * 15/HLA-DRB1 * 11 haplotype in CP compared to controls (total samples: 0.0% versus 4.3%, = 0.04; nonsmokers: 0 versus 5.1%, = 1.0). In conclusion, the HLA-A
    Mediators of Inflammation 09/2015; 2015:8. DOI:10.1155/2015/481656 · 3.24 Impact Factor
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    • "linkage disequilibrium seemed to exist between associated alleles. The positive association of HLA-A9 and HLA-B15 with AP in Caucasians [10] [12] [13] but not in Lebanese is also probably accounted for by the ethnic differences between the two populations. In addition, HLADRB1*13 seemed to have a more frequent occurrence in patients with AP that are Germans of Caucasian descent [26] and HLA-B*15 was also found to be associated with AP in Indian population [27]. "
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    ABSTRACT: Background: Periodontal disease, which affects tooth-supporting structures, results from disequilibrium between the oral micro flora and host defense mecha-nisms. It has been classified into chronic (CP) or ag-gressive (AP) periodontitis according to disease onset, localization and progression. Because of their invol-vement in generating immune responses, Human Leukocyte Antigen (HLA) alleles are considered can-didate genetic risk markers for periodontitis. Addi-tionally, periodontitis appears to contribute to the severity of some systemic conditions such as cardio-vascular disease and adverse pregnancy outcome as indicated by elevated levels of C-reactive protein (CRP). Aim: The aims of this study were to deter-mine if there is an HLA-AP association in Lebanese patients, and to determine CRP levels in patients and compare them to those in healthy controls. Materials and methods: The study groups included 26 patients with AP and 39 healthy controls. HLA profiles were determined by DNA typing and CRP levels by ELI-SA. Results: HLA-A*30 (P-value = 0.010), HLA-B*41 (P 1 = 0.012 and P 2 = 0.014), HLA-DRB1*13 (P 1 = 0.031 and P 2 = 0.063) alleles seemed to be associ-ated with protection against AP in Lebanese patients. No linkage disequilibrium existed between alleles associated with AP. Ten of 26 AP patients (38.5%) and 10 of 39 (25.7%) controls had elevated CRP lev-els. Conclusion: In conclusion, protective, but no sus-ceptible HLA alleles were detected in AP. CRP levels were not elevated in the entire AP group, and were not significantly different from controls. No linkage disequilibrium existed between alleles.
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