Article

Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event.

Department of Microbiology, ID-CEDD, GlaxoSmithKline, Collegeville, Pennsylvania 19426, USA.
Antimicrobial Agents and Chemotherapy (impact factor: 4.84). 04/2008; 52(3):1156-8. DOI:10.1128/AAC.00923-07 pp.1156-8
Source: PubMed

ABSTRACT While most Staphylococcus aureus telithromycin-resistant mutants isolated in this study possessed duplications within rplV (encoding ribosomal protein L22), four isolates possessed insertions within rplV that were identical to a portion of the gene rplB (encoding ribosomal protein L2). This novel type of mutation is the result of an apparent gene conversion-like event.

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Keywords

duplications
 
encoding ribosomal protein L2
 
encoding ribosomal protein L22
 
gene rplB
 
identical
 
rplV
 
Staphylococcus aureus telithromycin-resistant mutants