Infection rates and healing using bone wax and a soluble polymer material.

Division of Plastic and Reconstructive Surgery, the Department of Neurosurgery, University of Southern California, 536 S Rimpau Blvd, Los Angeles, CA 90020, USA.
Clinical Orthopaedics and Related Research (Impact Factor: 2.88). 03/2008; 466(2):481-6. DOI: 10.1007/s11999-007-0067-5
Source: PubMed

ABSTRACT The effects of using a newly available water-soluble polymer bone hemostatic material in a contaminated environment were assessed in a rabbit tibial defect model. Infection rates and healing of polymer-treated bone were compared with the infection and healing of bone wax-treated bone and untreated controls after a bacterial challenge. Defects created in 24 rabbit tibias were treated with the polymer or bone wax, or left without a hemostatic agent. The defects were inoculated with Staphylococcus aureus ATCC-29213 (2.5 x 10(4) colony-forming units). After 4 weeks, all defects treated with bone wax were infected and osteomyelitis had developed, and none had evidence of bone healing. In the polymer and control groups, two defects in each group (25%) had osteomyelitis develop. The remaining six defects in each group (75%) showed no osteomyelitis and exhibited normal bone healing. The polymer-treated defects had a considerably lower rate of osteomyelitis and positive bone cultures compared with the bone wax-treated group. There were no differences between the polymer-treated and control groups in the rates of osteomyelitis, positive cultures, or bone healing. The use of a soluble polymer as an alternative to bone wax may decrease the rates of postoperative bone infections.

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    ABSTRACT: Abstract: Controversial role of different local haemostatic agents on bone healing represented a major challenge for oral & maxillofacial surgeons. So, this study was directed to evaluate the effect of water soluble alkylene copolymer hemostat (ostene) versus bone wax on bone healing. Material & Methods: Forty five adult male rabbits weight 1kg were divided into three equal groups. A surgical bone defect was created into the anterior mandibular area. In 1st group the surgical defects were not subjected to any of local haemostatic agents. In 2nd group water soluble alkylene copolymer was applied within surgical defect and bone wax was applied within the 3rd group. Postoperatively, 3 animals were sacrificed from each group at 1, 2, 3, 6 and 12 weeks for histological assessment through H&E and Trichrome stain Results: Water soluble alkylene copolymer hemostat treated defects showed faster healing rate in 1st, 2nd weeks than defects left untreated. Ostene was disappeared from surgical defect at 1st week without presence of inflammatory cells in the defect. In 3rd group, the defects showed large empty vacuoles, representing bone wax remnants with inflammatory cells infiltration that interfere bone healing. Conclusion: Water soluble alkylene copolymer is biodegradable material that does not interfere with bone healing in contrast with bone wax which causes foreign body reaction, leading to interference of bone healing.
    Journal of American Science. 01/2010; 6(12):155-163.

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