Electronic nose: current status and future trends.

Institute of Physical and Theoretical Chemistry, University of Tübingen, Auf der Morgenstelle 15, Tübingen, Germany.
Chemical Reviews (Impact Factor: 45.66). 03/2008; 108(2):705-25. DOI: 10.1021/cr068121q
Source: PubMed
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    ABSTRACT: An early diagnosis and appropriate treatment are crucial in reducing mortality among people suffering from cancer. There is a lack of characteristic early clinical symptoms in most forms of cancer, which highlights the importance of investigating new methods for its early detection. One of the most promising methods is the analysis of volatile organic compounds (VOCs). VOCs are a diverse group of carbon-based chemicals that are present in exhaled breath and biofluids and may be collected from the headspace of these matrices. Different patterns of VOCs have been correlated with various diseases, cancer among them. Studies have also shown that cancer cells in vitro produce or consume specific VOCs that can serve as potential biomarkers that differentiate them from noncancerous cells. This review identifies the current challenges in the investigation of VOCs as potential cancer biomarkers, by the critical evaluation of available matrices for the in vivo and in vitro approaches in this field and by comparison of the main extraction and detection techniques that have been applied to date in this area of study. It also summarises complementary in vivo, ex vivo, and in vitro studies conducted to date in order to try to identify volatile biomarkers of cancer.
    03/2015; 2015. DOI:10.1155/2015/981458
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    ABSTRACT: Saffron is the commercial name of the dried stigmas of Crocus sativus L. flower. Due to the high cost of saffron, adulteration sometimes occurs in the local market. In this study, the aroma fingerprints of saffron, saffron with yellow styles, safflower, and dyed corn stigma were detected by an electronic nose system. The features of the obtained signals from electronic nose system were extracted and used for data analysis. In this work, principal component analysis was used and the results were confirmed by back propagation artificial neural networks. The results revealed that the system can recognize the saffron adulteration satisfactorily. As a conclusion, it was found that the electronic nose could provide good separation of the saffron and adulterated one (safflower and other adulteration) as 100 and 86.87% classification accuracy, respectively, by means of artificial neural networks. The electronic nose was able to differentiate non-adulterated and adulterated saffron at higher than 10% adulteration level successfully.
    International Journal of Food Properties 01/2015; 18:1391-1401. DOI:10.1080/10942912.2014.915850 · 0.91 Impact Factor
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    ABSTRACT: Lung cancer (LC) is known as the most common cancers and becoming the leading cause of cancer related death in human. The high mortality in lung cancer patient occurs because of lack of efficient methods to diagnose the disease at an early stage. In this review, we highlighted the studies conducted on compounds in exhaled air breath and metabolic pathway alteration in lung cancer patient, which may influence the alterations of volatile organic compounds (VOCs) in exhaled air breath. This review has shown that VOCs from exhaled air breath of lung cancer patient has potential to be used as lung cancer biomarker to diagnose lung cancer at primary stage by developing advanced technology of electronic nose system. Index Terms— lung cancer, exhaled air breath, metabolic alteration, volatile organic compounds (VOCs), electronic nose system.
    2014 IEEE 5th Control and System Graduate Research Colloquium, UiTM, Shah Alam, Malaysia; 08/2014

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