Oxaliplatin-induced immune mediated thrombocytopenia.

Department of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Cancer Chemotherapy and Pharmacology (Impact Factor: 2.57). 02/2008; 62(5):925-7. DOI: 10.1007/s00280-007-0675-5
Source: PubMed

ABSTRACT Oxaliplatin is a third generation platinum compound used in patients with advanced colorectal carcinoma. Recently, the mechanism of a rare drug-induced immune thrombocytopenia in patients receiving oxaliplatin has been described. This complication is caused by oxaliplatin-dependent antibodies directed against platelet surface glycoproteins, and is unrelated to myelosuppression. In this report, we describe two patients who developed thrombocytopenia immediately soon after receiving oxaliplatin. Sensitization presumably had occurred after receiving oxaliplatin during preceding courses of multiagent chemotherapy that included oxaliplatin.

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