Chromosome Bi-Orientation: Euclidian Euploidy

Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA.
Current Biology (Impact Factor: 9.57). 02/2008; 18(2):R81-3. DOI: 10.1016/j.cub.2007.11.036
Source: PubMed


Establishment of proper attachments between chromosomes and microtubules is essential for the accurate division of the genome. Two recent studies indicate that these attachments are facilitated by the geometry of chromosomes and the bipolar arrangement of spindle microtubules.


Available from: Jason Stumpff, Jan 14, 2015
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Fidelity during chromosome segregation is essential to prevent aneuploidy. The proteins and chromatin at the centromere form a unique site for kinetochore attachment and allow the cell to sense and correct errors during chromosome segregation. Centromeric chromatin is characterized by distinct chromatin organization, epigenetics, centromere-associated proteins and histone variants. These include the histone H3 variant centromeric protein A (CENPA), the composition and deposition of which have been widely investigated. Studies have examined the structural and biophysical properties of the centromere and have suggested that the centromere is not simply a 'landing pad' for kinetochore formation, but has an essential role in mitosis by assembling and directing the organization of the kinetochore.
    Nature Reviews Molecular Cell Biology 05/2011; 12(5):320-32. DOI:10.1038/nrm3107 · 37.81 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The proper organization and segregation of chromosomes during cell division is essential to the preservation of genomic integrity. To understand the mechanisms that spatially control the arrangement and dynamics of mitotic chromosomes requires imaging assays to quantitatively resolve their positions and movements. Here, we will discuss analytical approaches to investigate the position-dependent control of mitotic chromosomes in cultured cells. These methods can be used to dissect the specific contributions of mitotic proteins to the molecular control of chromosome dynamics. J. Cell. Physiol. 9999: XX-XX, 2014. © 2014 Wiley Periodicals, Inc.
    Journal of Cellular Physiology 10/2014; 229(10). DOI:10.1002/jcp.24634 · 3.84 Impact Factor