New players in the regulation of ecdysone biosynthesis.

Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Journal of Genetics and Genomics (Impact Factor: 2.92). 02/2008; 35(1):1-10. DOI: 10.1016/S1673-8527(08)60001-6
Source: PubMed

ABSTRACT Insect ecdysone steroid hormone regulates major developmental transitions, such as molting and metamorphosis. The production of ecdysone correlates well with the timing of these transitions. Finding out how the ecdysone biosynthesis is regulated is crucial to fully understand these sophisticated developmental switches. Here we summarized recent findings in the regulation of ecdysone biosynthesis from the aspects of cell signaling, key biosynthetic enzymes and substrate cholesterol trafficking.

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