Article

Cup-like acute myeloid leukemia: new disease or artificial phenomenon?

First Medical Department, Dresden University Hospital, Dresden, Germany.
Haematologica (impact factor: 6.42). 03/2008; 93(2):283-6. DOI:10.3324/haematol.11669 pp.283-6
Source: PubMed

ABSTRACT We investigated cup-like nuclear morphology of acute myeloid leukemia blasts in 266 randomly selected patients and its association with hematologic findings, disease markers and outcome data. Cup-like acute myeloid leukemia was diagnosed in 55 patients (21%). It was associated with female sex, high white blood cell and blast cell counts, normal karyotype, and low CD34 and HLA-DR expression. Mutations of FLT3, NPM1 or both were detected in 84.9% compared with 58.1% in cases without this morphology (p=0.001). There was no influence on response to treatment or survival. Therefore, cup-like nuclear morphology is an indicator of normal karyotype and should guide more specific molecular analyses.

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Keywords

55 patients
 
acute myeloid leukemia blasts
 
Cup-like acute myeloid leukemia
 
cup-like nuclear morphology
 
disease markers
 
hematologic findings
 
HLA-DR expression
 
normal karyotype
 
NPM1
 
outcome data
 
white blood cell
 

Frank P Kroschinsky