Cervical metastasis from Spitz nevus of the buccal mucosa

Departments of aOto-Rhino-Laryngology/Head and Neck Surgery,Rikshospitalet Medical Center, University of Oslo, Oslo, Norway.
Melanoma Research (Impact Factor: 2.28). 03/2008; 18(1):36-9. DOI: 10.1097/CMR.0b013e3282f356e4
Source: PubMed


A 23-year-old woman was presented with a prolonged history of a small lump in the buccal mucosa. A local excision was performed. The morphology diagnosed a Spitz nevus and she underwent supplementary excision of scar tissue. Two years later a submandibular lump appeared on the ipsilateral side of the neck. Cytology from fine needle aspiration indicated spread of a melanocytic tumor and she underwent a modified supraomohyiod neck dissection. One of the lymph nodes showed an inclusion of cells in the deep layers with epitheloid and spindle cells in a pattern similar to that of the primary oral lesion. The finding suggests a mechanical spread of melanocytes from the Spitz nevus to the regional lymph node. After more than 3 years of follow-up there is no further manifestation of disease. It is believed that this may be an example of how a Spitz tumor, although inherently benign, can spread along lymphatics in a pseudometastatic fashion. To our knowledge this is the first report of an oral Spitz melanoma with metastatic behavior.

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