[The progress in researches on biocompatibility for direct brain-machine interface].

Key Laboratory of Laboratory Medical Diagnostics of Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China.
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 01/2008; 24(6):1416-8.
Source: PubMed


An important application of the direct brain-machine interfaces are providing an outlet for severely paralyzed individuals to communicate with the world. According to different type of microelectrodes, brain-machine interfaces are divided into indirect-BMI and direct-BMI. Direct-BMI are intracortical recording devices designed to capture the action potentials of many individual neurons, especially those that code for movement or its intent. A key problem in research of BMI is how to enhance biocompatibility for direct-BMI. This review introduces some new microelectrodes of direct brain-machine interface which all have higher biocompatibility.

9 Reads
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A brain-machine interface (BMI) is a neuroprosthetic device that can restore motor function of individuals with paralysis. Although the feasibility of BMI control of upper-limb neuroprostheses has been demonstrated, a BMI for the restoration of lower-limb motor functions has not yet been developed. The objective of this study was to determine if gait-related information can be captured from neural activity recorded from the primary motor cortex of rats, and if this neural information can be used to stimulate paralysed hindlimb muscles after complete spinal cord transection. Neural activity was recorded from the hindlimb area of the primary motor cortex of six female Sprague Dawley rats during treadmill locomotion before and after mid-thoracic transection. Before spinal transection there was a strong association between neural activity and the step cycle. This association decreased after spinal transection. However, the locomotive state (standing vs. walking) could still be successfully decoded from neural recordings made after spinal transection. A novel BMI device was developed that processed this neural information in real-time and used it to control electrical stimulation of paralysed hindlimb muscles. This system was able to elicit hindlimb muscle contractions that mimicked forelimb stepping. We propose this lower-limb BMI as a future neuroprosthesis for human paraplegics.
    PLoS ONE 08/2014; 9(8):e103764. DOI:10.1371/journal.pone.0103764 · 3.23 Impact Factor

Similar Publications