Does "ichthyosis uteri" have malignant potential? : A case report of squamous cell carcinoma of endometrium associated with extensive ichthyosis uteri
ABSTRACT Ichthyosis uteri is a rare condition in which the entire surface of the endometrium is replaced by stratified squamous epithelium. Though the condition often is considered as benign, anaplastic and dysplastic changes have been reported. We describe herein a rare case of low-grade squamous cell carcinoma of endometrium associated with extensive ichthyosis uteri with dysplasia. The cervix showed moderate to severe dysplastic changes while the right fallopian tube showed extensive squamous metaplasia with dysplastic changes. We conclude that squamous cell carcinoma could develop into pre-existing ichthyosis uteri.
Full-textDOI: · Available from: Thangarajan Rajkumar, Sep 28, 2015
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- "Endometrial SCCs may originate from heterotopic cervical epithelium within the endometrium14 or from reserve or progenitor cells located between the glandular basement membrane and the endometrial columnar epithelium.15 Hormonal stimulation, pelvic irradiation, vitamin A deficiency, chronic irritation (such as pyometra), chronic endometritis, uterine prolapse or eversion, an intrauterine device, and external irritants may predispose patients to squamous metaplasia and subsequent malignant transformation,13,16-18 but an association with HPV infection has not been documented. By contrast, p16INK4a, a surrogate marker for HPV infection, is consistently positive in HPV-associated cervical carcinomas.9 "
ABSTRACT: Primary squamous cell carcinoma (SCC) of the upper genital tract, including the endometrium, fallopian tubes, and ovaries, is extremely rare. It must be distinguished from the mucosal extension of primary cervical SCC because determination of the primary tumor site is important for tumor staging. However, patients with SCC of the fallopian tubes or ovarian surface have often undergone prior hysterectomy with inadequate examination of the cervix, making it difficult to determine the primary site. We compared histologic findings, p16(INK4a) expression, and human papillomavirus (HPV) DNA status in four patients with primary SCC of the upper genital tract and five patients with primary cervical SCC extending to the mucosa of the upper genital tract. All five SCCs of cervical origin showed strong expression of p16(INK4a), whereas all four SCCs of the upper genital tract were negative, although one showed weak focal staining. Three of the five cervical SCCs were positive for HPV16 DNA, whereas all four primary SCCs of the upper genital tract were negative for HPV DNA. Although a thorough histological examination is important, immunonegativity for p16(INK4a) and negative for HPV DNA may be useful adjuncts in determining primary SCCs of the upper genital tract.The Korean Journal of Pathology 12/2013; 47(6):549-56. DOI:10.4132/KoreanJPathol.2013.47.6.549 · 0.17 Impact Factor
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ABSTRACT: Advantages of the laser Doppler velocimetry method, as well as current status are reviewed. The unique problems of applying this tecnnique to sediment transport studies in the deep sea are discussed, followed by how these problems were overcome. An autonomous two-axis backscatter instrument is described which profiles the horizontal velocity in the bottom 0-0.5 m of the benthic boundary layer under microprocessor control. Data is stored as velocity time series on a Sea Data tape recorder following in-situ processing of the Doppler signal.Current Measurement, Proceedings of the 1982 IEEE Second Working Conference on; 02/1982
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ABSTRACT: Clinicopathologic studies support a classification of endometrial carcinoma into two main categories (type I and type II). Type I cancers consist of endometrioid and mucinous carcinomas, with the former being the most common, whereas serous and clear cell carcinomas are the so-called "prototype" of type II cancers. Nonendometrioid carcinomas account for approximately 10% of endometrial carcinomas and differ from endometrioid carcinomas in terms of patient demographics, morphologic features, and biological behavior. Molecular studies have provided further insights into the differing alterations involved in the development and progression of these tumors. This review summarizes the characteristic clinical, morphologic, immunophenotypic, and molecular features of the various subtypes of nonendometrioid carcinomas and also highlights relevant conditions (both nonneoplastic and neoplastic) that should be considered in the differential diagnosis of these tumors.Seminars in Diagnostic Pathology 11/2010; 27(4):241-60. DOI:10.1053/j.semdp.2010.09.004 · 2.56 Impact Factor