Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill.

Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Journal of Ethnopharmacology (Impact Factor: 2.94). 12/2003; 89(1):67-71. DOI: 10.1016/S0378-8741(03)00234-4
Source: PubMed

ABSTRACT Extracts obtained from the leaves of Lavandula angustifolia Mill. (Lamiaceae) are used in Iranian folk medicine as remedies for the treatment of various inflammatory diseases. For evaluation of its probable analgesic and anti-inflammatory effects, hydroalcoholic extract, polyphenolic fraction and essential oil of the leaves of the herb were prepared and their analgesic effects were studied in mice using formalin and acetic acid-induced writhing tests. Carrageenan test in rats was used for assessment of anti-inflammatory activity of above-mentioned fractions. Results showed that while the hydroalcoholic extract (400-1600 mg/kg, p.o.) inhibited only the second phase of formalin test, the polyphenolic fraction (800 and 1600 mg/kg, p.o.) and essential oil (100 and 200 mg/kg, p.o.) suppressed both phases. In acetic acid-induced writhing test, polyphenolic fraction (400 and 800 mg/kg, p.o.) and essential oil (100 and 200 mg/kg, p.o.) reduced the number of abdominal constrictions. Essential oil at a dose of 200mg/kg also inhibited carrageenan-induced paw edema. Results of the present study confirm the traditional use of Lavandula angustifolia for the treatment of painful and inflammatory conditions and calls for further investigations to determine the active chemical constituent(s).


Available from: Alireza Ghannadi, Feb 09, 2014
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Lavender remedies have been used in traditional medicine because of antimicrobial, anti-inflammatory and mood alleviating effects, but underlying molecular mechanisms are not fully elucidated. Recently, studies investigating the effects of lavender oil in the context of psychiatric disorders have indicated potent pharmacological properties. Metabolism of tryptophan by indoleamine 2,3-dioxygenase (IDO) was found to provide a biochemical link between immunology and neuroendocrinology and to be a frequent target of natural products. In this in vitro study, interferences of lavender oil and constituents (-)-linalool, (+)-alpha-pinene and (+)-limonene with tryptophan catabolism by IDO and formation of neopterin via guanosine triphosphate (GTP)-cyclohydrolase-I and of interferon-gamma have been investigated using unstimulated and phytohemagglutinin (PHA)-stimulated human peripheral blood mononuclear cells (PBMC). Treatment with lavender oil dose-dependently suppressed PHA-induced tryptophan breakdown and kynurenine formation. Similar effects were observed for the three constituents. In parallel, formation of neopterin and interferon-gamma was diminished upon lavender oil treatment. In unstimulated PBMC, effect of lavender oil treatment was similar, but less pronounced. Data from this in vitro study suggest that lavender oil treatment might contribute to the modulation of the immune and neuroendocrine system by interfering with activation-induced tryptophan breakdown and IDO activity.
    BMC Complementary and Alternative Medicine 12/2014; 14(1):503. DOI:10.1186/1472-6882-14-503 · 1.88 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: With the purpose of valorizing the flora and ethnopharmacological heritage of the Meknès-Tafilalet area in Morocco, an ethnobotanical study has been carried out into the cooperatives and associations operating in the domain of the aromatic and medicinal plants of this area. This study enabled us to inventory 30 exploited species, distributed 12 families, at a production of approximately 494 tons of plants dried a year. A very significant part of the receipts is recommended for the treatment of some disorders of the digestive, nervous and cutaneous systems. The leaves constitute the most used part. The most frequently employed modes of preparation for the majority of the remedies are the decoction (29%), the infusion (25%) and then the maceration (23%).
    Phytotherapie 12/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: In the past Alpine populations were isolated from comforts of industrial and technological development present in large cities and, therefore, they were obliged to find in nature a source of sustenance and care. Traditional use of plant is a wealth of local knowledge that is likely to be lost. This work, carried out during 2012, aims to collect, analyze and process information on the species used for medicinal, veterinary, cosmetic, domestic, ritual and religious purposes by the inhabitants of Valfurva, in the Province of Sondrio (Italy). Furthermore it is a means for the preservation of local traditions regarding such uses and increases the ethnobotanical data from Northern Italy, till now poorly documented.
    Journal of Ethnopharmacology 01/2015; 163. DOI:10.1016/j.jep.2014.12.054 · 2.94 Impact Factor