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Cortico-cortical networks in patients with ideomotor apraxia as revealed by EEG coherence analysis.

Lewis A Wheaton, Stephan Bohlhalter, Guido Nolte, Hiroshi Shibasaki, Noriaki Hattori, Esteban Fridman, Sherry Vorbach, Jordan Grafman, Mark Hallett

Human Motor Control Section, NINDS, NIH, Bethesda, MD 20892-1428, United States.

Journal Article: Neuroscience Letters (impact factor: 1.93). 04/2008; 433(2):87-92. DOI: 10.1016/j.neulet.2007.12.065

Abstract

We sought to determine whether coherent networks which circumvent lesioned cortex are seen in patients with ideomotor apraxia (IMA) while performing tool-use pantomimes. Five normal subjects and five patients with IMA (three patients with corticobasal degeneration and two with left hemisphere stroke) underwent 64-channel EEG recording while performing three tool-use pantomimes with their left hand in a self-paced manner. Beta band (20-22 Hz) coherence indicates that normal subjects have a dominant left hemisphere network responsible for praxis preparation, which was absent in patients. Corticobasal degeneration patients showed significant coherence increase between left parietal-right premotor areas. Left hemisphere stroke patients showed significant coherence increases in a right parietofrontal network. The right hemisphere appears to store useable praxis representations in IMA patients with left hemisphere damage.

Source: PubMed

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Keywords

64-channel EEG recording
 
circumvent lesioned cortex
 
coherent networks
 
corticobasal degeneration
 
Corticobasal degeneration patients
 
hemisphere damage
 
hemisphere network responsible
 
hemisphere stroke
 
Left hemisphere stroke patients
 
normal subjects
 
parietal-right premotor areas
 
parietofrontal network
 
self-paced manner
 
significant coherence increase
 
significant coherence increases
 
tool-use pantomimes