Measles vaccination and antibody response in autism spectrum disorders

Newcomen Centre for Child Development, Guy's & St Thomas' NHS Foundation Trust, London, UK.
Archives of Disease in Childhood (Impact Factor: 2.9). 03/2008; 93(10):832-7. DOI: 10.1136/adc.2007.122937
Source: PubMed


To test the hypothesis that measles vaccination was involved in the pathogenesis of autism spectrum disorders (ASD) as evidenced by signs of a persistent measles infection or abnormally persistent immune response shown by circulating measles virus or raised antibody titres in children with ASD who had been vaccinated against measles, mumps and rubella (MMR) compared with controls.
Case-control study, community based.
A community sample of vaccinated children aged 10-12 years in the UK with ASD (n = 98) and two control groups of similar age, one with special educational needs but no ASD (n = 52) and one typically developing group (n = 90), were tested for measles virus and antibody response to measles in the serum.
No difference was found between cases and controls for measles antibody response. There was no dose-response relationship between autism symptoms and antibody concentrations. Measles virus nucleic acid was amplified by reverse transcriptase-PCR in peripheral blood mononuclear cells from one patient with autism and two typically developing children. There was no evidence of a differential response to measles virus or the measles component of the MMR in children with ASD, with or without regression, and controls who had either one or two doses of MMR. Only one child from the control group had clinical symptoms of possible enterocolitis.
No association between measles vaccination and ASD was shown.

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Available from: David W G Brown, Oct 26, 2015
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    • "This includes a study where the MMR vaccine was administered for a 4-year period (1989–1993) in Japan; the incidence of autism was not different across the interval before, during, and after this MMR vaccination window (95). Baird et al. (96) reported no dose response associations between the antibody response to measles virus or the measles component of the MMR in children with autism versus two control groups of children (one control group with specific educational needs unrelated to autism and a typically developing group of children). In a very recent case-controlled study, Mrozek-Budzyn et al. (97) found no association between either MMR vaccination or single measles vaccine administration and risk of autism. "
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    ABSTRACT: Autism is a devastating childhood condition that has emerged as an increasing social concern just as it has increased in prevalence in recent decades. Autism and the broader category of autism spectrum disorders are among the increasingly seen examples in which there is a fetal basis for later disease or disorder. Environmental, genetic, and epigenetic factors all play a role in determining the risk of autism and some of these effects appear to be transgenerational. Identification of the most critical windows of developmental vulnerability is paramount to understanding when and under what circumstances a child is at elevated risk for autism. No single environmental factor explains the increased prevalence of autism. While a handful of environmental risk factors have been suggested based on data from human studies and animal research, it is clear that many more, and perhaps the most significant risk factors, remain to be identified. The most promising risk factors identified to date fall within the categories of drugs, environmental chemicals, infectious agents, dietary factors, and other physical/psychological stressors. However, the rate at which environmental risk factors for autism have been identified via research and safety testing has not kept pace with the emerging health threat posed by this condition. For the way forward, it seems clear that additional focused research is needed. But more importantly, successful risk reduction strategies for autism will require more extensive and relevant developmental safety testing of drugs and chemicals.
    Emerging Health Threats Journal 04/2011; 4(1):7111. DOI:10.3402/ehtj.v4i0.7111
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    • "In addition to the epidemiologic reports examining the relationship between MMR vaccine and autism, others have tried to replicate the findings of measles virus RNA in children with autism. Three studies (Afzal et al., 2006; D'Souza, 2006; Baird et al., 2008) have found no difference in the prevalence of measles virus in peripheral blood mononuclear cells between children with autism and controls, or failed to find any virus in either group. Martin et al. (2002) did find measles virus RNA more commonly in the bowel tissue of children with autism and regression compared to a group of controls, using a variety of polymerase chain reaction methods. "
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    ABSTRACT: PURPOSE. The purpose of this article is to review relevant background literature regarding the evidence linking thimerosal-containing vaccine and the measles, mumps, and rubella vaccine to autism. CONCLUSIONS. Rigorous scientific studies have not identified links between autism and either thimerosal-containing vaccine or the measles, mumps, and rubella vaccine. PRACTICE IMPLICATIONS. Nurses are often in the position of providing advice regarding vaccines in their formal practice areas as well as in their daily lives. Families need current and credible evidence to make decisions for their children. Excellent vaccine information resources are available online.
    Journal for Specialists in Pediatric Nursing 07/2009; 14(3):166 - 172. DOI:10.1111/j.1744-6155.2009.00194.x · 0.92 Impact Factor
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