Antibiotics and antiseptics for venous leg ulcers

University of York, Health Sciences, Area 3 Seebohm Rowntree Building, Heslington, York, UK YO10 5DD.
Cochrane database of systematic reviews (Online) (Impact Factor: 6.03). 02/2008; 14(1):CD003557. DOI: 10.1002/14651858.CD003557.pub2
Source: PubMed


Venous leg ulcers are a type of wound that can take a long time to heal. These ulcers can become infected and this might cause further delay to healing. Two types of treatment are available to treat infection: systemic antibiotics (i.e. antibiotic tablets or injections) and topical preparations (i.e. applied directly to the wound). Whether systemic or topical preparations are used, patients will also usually have a wound dressing to cover the wound and maybe a bandage too. This review was undertaken in order to find out whether using antibiotics and antiseptics works better than usual care for healing venous leg ulcers, and if so, to find out which antibiotic and antiseptic preparations are better than others. In terms of topical preparations, there is some evidence to support the use of cadexomer iodine. Further good quality research is required before definitive conclusions can be made about the effectiveness of systemic antibiotics and topical agents such as povidone iodine, peroxide-based preparations, ethacridine lactate and mupirocin in healing venous leg ulceration.

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    • "Clinicians have long been searching for ways to obtain "super normal" healing of wounds using different models (5-7). These investigators found thiamine (vitamin B1) (8), pantothenic acid (vitamin B5) (3, 9,10) riboflavin (11), ascorbic acid (vitamin C) (12,13) vitamin A(14), cortisone (15,16), vitamin E (17,18), copper (19), manganese and silicone (19-22), and CO2 laser (23) effective on wound healing process. Among them, one managed to show that zinc supplementation would result in the improved healing of granulating open wounds (24-28). "
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    ABSTRACT: Clinicians have long been searching for ways to obtain "super normal" wound healing. Zinc supplementation improves the healing of open wounds. Honey can improve the wound healing with its antibacterial properties. Giving supplemental zinc to normal rats can increase the wound tensile strength. This work is to study the concurrent effects of zinc and honey in wound healing of normal rats. ONE HUNDRED AND SEVENTY TWO YOUNG RATS WERE RANDOMLY DIVIDED INTO FOUR GROUPS: control, zinc-supplement, applied honey, zinc-supplement and applied honey. Two areas of skin about 4 cm² were excised. The wound area was measured every 2 days. After 3 weeks, all animals were killed and tensile strength of wounds, zinc concentration of blood and histological improvement of wounds were evaluated. The results were analyzed using two-way ANOVA and the mean differences were tested. It was found that honey could inhibit the bacterial growth in skin excisions. The tensile strength was increased significantly in the second to fourth groups at 21st day (P< 0.001). Also there was a significant increase in tensile strength at the same time in the fourth group. The results of the histological study showed a considerable increase in the collagen fibers, re-epithelialization and re-vascularization in the second to fourth groups. The results of the present study indicate that zinc sulfate could retard re-epithelialization, but when used with natural honey (administered topically) it could have influent wound healing in non-zinc-deficient subjects as well.
    Iranian Journal of Basic Medical Science 03/2011; 14(4):391-398. · 1.23 Impact Factor
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    • "Iodine has excellent broad-spectrum antimicrobial activity but should be used with caution in patients with thyroid disease and in pregnancy. In particular, topical application of cadexomer iodine has been found to be effective for healing venous leg ulcers.19 Iodine dressings should be changed every other day. "
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    ABSTRACT: This article reviews the current recommendations for the classification and treatment of chronic wounds. With a rational approach and a thorough understanding of available treatment options, plastic surgeons can provide better-quality and more cost-effective wound care. The authors reviewed the literature on the history of wound care and on recent advancements in wound care and also summarized the current clinical practices of the Johns Hopkins Wound Center. n/a. Optimized wound dressings decrease pain, diminish morbidity, and improve healing times.
    Eplasty 02/2009; 9:e14.
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    ABSTRACT: Varicose ulcers represent a major issue for both patients and health services being associated with impaired quality of patient's life and loss of work productivity. Many of these chronic wounds are associated with infections. The study group has included 662 bacterial strains isolated from secretions of the infected varicose ulcers of patients treated in the Dermatology department from the Clinical County Emergency Hospital Braşov between 2007 and 2008. The objective of our study has consisted in the evaluation of etiological spectrum of varicose infections and resistance to antibiotics of implicated microbes. The most frequent involved germ was Staphylococcus aureus (58.3%), followed by Enterobacter spp (14.8%) and Pseudomonas aeruginosa (9.5%). Lower frequencies of isolation were registered for Escherichia coli, Proteus mirabilis, Acinetobacter spp and Klebsiella spp. Various levels of bacterial resistance were registered for the tested antibiotics. .
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