Evaluation of serum selenium levels in Turkish women with gestational diabetes mellitus, glucose intolerants, and normal controls.
ABSTRACT The aim of the study was to investigate the association between serum selenium levels in patients with gestational diabetes mellitus (GDM) and glucose intolerants and compare them with those of glucose-tolerant pregnant women. This cross-sectional study was prospectively performed in a total of 178 pregnant women undergoing a 50-g oral glucose tolerance test between 24 and 28 weeks of gestation who were grouped according to their status of glucose tolerance as with gestational diabetes (group A, abnormal 1- and 3-h glucose tolerance test; n = 30), glucose intolerant (group B, abnormal 1-h but normal 3-h glucose tolerance test; n = 47), or normal controls (group C, normal 1-h glucose test; n = 101). Serum selenium levels were measured with a graphite furnace atomic absorption spectrophotometer using a matrix modifier. Median maternal age and gestational age at the time of diagnosis in group A (gestational age = 24.8 [24-27]), group B (gestational age = 24.7 [24-27]), and group C (gestational age = 25 [24-28]) did not differ. Patients with gestational diabetes mellitus and those with glucose intolerants had lower selenium level than that of the normal pregnant women (P < 0.001). There was a significant inverse correlation between selenium and blood glucose level, and also selenium supplementation might prove beneficial on patients with GDM and prevent or retard them from secondary complications of diabetes.
Conference Paper: Team/Design: an object-based system for concurrent engineering[Show abstract] [Hide abstract]
ABSTRACT: Team/Design is an object-oriented, knowledge-based software tool developed for concurrent engineering design of both complex and simple systems. It enhances design decision-making by enabling consideration of and trade off among multiple design goals, specifications and constraints, and selection among alternatives to create the total quality product. The original impetus behind the development of Team/Design was the recognition of the need to create a flexible, effective design modeling and decision support system for concurrent engineering/system engineering. The method enhances the total quality (eg., cost performance, supportability, producibility, schedule) of the resulting product while increasing the efficiency of the design process. Object-oriented user interface techniques provide a natural approach to enable systems engineers and other design engineers to model and analyze an early-stage design from the concurrent engineering viewpoint. The development of Team/Design has shown the object-oriented, methodology to be viable for concurrent engineering decision supportReliability and Maintainability Computer-Aided Engineering in Concurrent Engineering, 1990 and 1991., Combined Proceedings of the 1990 and 1991 Leesburg Workshops on; 02/1992
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ABSTRACT: Placental type 3 iodothyronine deiodinase (D3) potentially protects the fetus from the elevated maternal thyroid hormones. Na(+)/I(-) symporter (NIS) is a plasma membrane glycoprotein, which mediates active iodide uptake. Our objectives were to establish the distribution of NIS and D3 gene expressions in the placenta and the amniotic membrane and to investigate the relationship between placental D3 and NIS gene expressions and maternal iodine, selenium, and thyroid hormone status. Thyroid hormones, urinary iodine concentration (UIC), and selenium levels were measured in 49 healthy term pregnant women. NIS and D3 gene expressions were studied with the total mRNA RT-PCR method in tissues from maternal placenta (n = 49), fetal placenta (n = 9), and amniotic membrane (n = 9). NIS and D3 gene expressions were shown in the fetal and maternal sides of the placenta and amniotic membrane. Mean blood selenium level was 66 ± 26.5 μg/l, and median UIC was 143 μg/l. We could not demonstrate any statistically significant relationship of spot UIC and blood selenium with NIS and D3 expression (p > 0.05). Positive correlations were found between NIS and thyroxine-binding globulin (TBG) (r = 0.3, p = 0.042) and between D3 and preoperative glucose levels (r = 0.4, p = 0.006). D3 and NIS genes are expressed in term placenta and amniotic membrane; thus, in addition to placenta, amniotic membrane contributes to regulation of maternofetal iodine and thyroid hormone transmission. Further studies are needed to clarify the relationship between maternal glucose levels and placental D3 expression and between TBG and placental NIS expression.Biological trace element research 07/2013; · 1.92 Impact Factor
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ABSTRACT: Selenium (Se) plays an important role in health maintenance, and optimization of Se status of the general population is an urgent task for many countries worldwide. Low Se availability from European soils due to fertilization decreased dramatically. Se availability for plants leads to low Se concentrations in grains and in animal-derived products and ultimately in human diet. Supplementing animal diets with Se in the form of sodium selenite or selenate does not affect substantially Se concentration in eggs, meat, and milk. SeMet represents the major form of Se in animal-derived foods and must be provided with diets for solving Se deficiency problems through production of Se-enriched eggs, meat, and milk. KeywordsSelenium-Antioxidants-Human health-Deficiency12/2009: pages 379-403;