Evaluation of Serum Selenium Levels in Turkish Women with Gestational Diabetes Mellitus, Glucose Intolerants, and Normal Controls

Department of Biochemistry, School of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, 46050, Turkey.
Biological Trace Element Research (Impact Factor: 1.75). 06/2008; 123(1-3):35-40. DOI: 10.1007/s12011-007-8087-2
Source: PubMed


The aim of the study was to investigate the association between serum selenium levels in patients with gestational diabetes mellitus (GDM) and glucose intolerants and compare them with those of glucose-tolerant pregnant women. This cross-sectional study was prospectively performed in a total of 178 pregnant women undergoing a 50-g oral glucose tolerance test between 24 and 28 weeks of gestation who were grouped according to their status of glucose tolerance as with gestational diabetes (group A, abnormal 1- and 3-h glucose tolerance test; n = 30), glucose intolerant (group B, abnormal 1-h but normal 3-h glucose tolerance test; n = 47), or normal controls (group C, normal 1-h glucose test; n = 101). Serum selenium levels were measured with a graphite furnace atomic absorption spectrophotometer using a matrix modifier. Median maternal age and gestational age at the time of diagnosis in group A (gestational age = 24.8 [24-27]), group B (gestational age = 24.7 [24-27]), and group C (gestational age = 25 [24-28]) did not differ. Patients with gestational diabetes mellitus and those with glucose intolerants had lower selenium level than that of the normal pregnant women (P < 0.001). There was a significant inverse correlation between selenium and blood glucose level, and also selenium supplementation might prove beneficial on patients with GDM and prevent or retard them from secondary complications of diabetes.

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    • "The overall data demonstrated that serum Se concentration is significantly lower in pregnant women with gestational hyperglycemia comparing to normal pregnant women (Fig. 2). Regarding the inverse correlation between level of Se and obesity [14], the non-significant result in the study of Al-Saleh et al. [16] might be due to diversity in BMI of cases and controls; the subjects were obese and BMI in cases was significantly lower than BMI in control group (P ≤ 0.05). Molnar et al. stated that because of the lack of sufficient data on plasma Se concentration of GDM cases, it was not possible to reach a distinct conclusion [15]. "
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    ABSTRACT: Background Results of the studies about association between serum selenium concentration and gestational hyperglycemia are inconsistent. Some studies have demonstrated that women with gestational diabetes mellitus (GDM) have lower Se concentrations while contrary results are reported in other studies. Aim The aim of this study is to compare the serum Se concentration in women with GDM and normoglycemic pregnant women via a systematic review and meta-analysis. Methods A computerized literature search on four databases (PubMed, Cochrane register of control trials, Scopus and Google scholar) was performed from inception through August 2013. Necessary data were extracted and random effects model was used to conduct the meta-analysis. Results Six observational studies (containing 147 women with GDM and 360 normoglycemic pregnant women) were found, which had compared serum Se concentration in women suffering from GDM with normal pregnant ones. Our meta-analysis revealed that serum Se concentration was lower in women with GDM compared to normoglycemic pregnant women (Hedges = -1.34; 95% CI: -2.33–- 0.36; P< 0.01). Stratified meta-analysis demonstrated that concentration of Se in the sera of women with GDM was lower than normal pregnant women both in second and third trimesters, but the result was not significant in second trimester (second trimester: Hedges = - 0.68; 95% CI: - 1.60–0.25; P = 0.15, third trimester: Hedges = - 2.81; 95% CI: - 5.21–- 0.42; P< 0.05). It was also demonstrated that serum Se status was lower in pregnant women with impaired glucose tolerance (IGT) compared to normoglycemic pregnant women (Hedges = - 0.85; 95% CI: -1.18–-0.52). Conclusion The available evidences suggest that serum Se concentration is significantly lower in pregnant women with gestational hyperglycemia compared to normal pregnant women.
    Journal of Trace Elements in Medicine and Biology 09/2014; 29. DOI:10.1016/j.jtemb.2014.09.006 · 2.37 Impact Factor
    • "The current study showed no significant differences in zinc and selenium levels between pregnant women with gestational diabetes and controls. This finding is in contrast to previous reports where pregnant women with gestational diabetes were observed to have lower levels of zinc and selenium levels (Tan et al. 2001; Bo et al. 2005; Kilinc et al. 2008). The explanation for this discrepancy between studies is unclear. "
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