Swine Workers and Swine Influenza Virus Infections

University of Iowa College of Public Health, Iowa City, Iowa, USA.
Emerging infectious diseases (Impact Factor: 7.33). 01/2008; 13(12):1871-8. DOI: 10.3201/eid1312.061323
Source: PubMed

ABSTRACT In 2004, 803 rural Iowans from the Agricultural Health Study were enrolled in a 2-year prospective study of zoonotic influenza transmission. Demographic and occupational exposure data from enrollment, 12-month, and 24-month follow-up encounters were examined for association with evidence of previous and incident influenza virus infections. When proportional odds modeling with multivariable adjustment was used, upon enrollment, swine-exposed participants (odds ratio [OR] 54.9, 95% confidence interval [CI] 13.0-232.6) and their nonswine-exposed spouses (OR 28.2, 95% CI 6.1-130.1) were found to have an increased odds of elevated antibody level to swine influenza (H1N1) virus compared with 79 nonexposed University of Iowa personnel. Further evidence of occupational swine influenza virus infections was observed through self-reported influenza-like illness data, comparisons of enrollment and follow-up serum samples, and the isolation of a reassortant swine influenza (H1N1) virus from an ill swine farmer. Study data suggest that swine workers and their nonswine-exposed spouses are at increased risk of zoonotic influenza virus infections.

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    ABSTRACT: The recent emergence of swine-origin H1N1 (swl) influenza virus that have transmitted to and spread among humans has fueled concerns that the outbreak is the start of a new pandemic. Many H1N1 swl influenza outbreaks have been registered internationally during the May–July 2009. In this paper, we investigate relations between the evolution of reported cases number and the effectiveness of pandemic control measures. Ten topics were considered representative from the first three months of pandemic spreading in Europe and the lessons were compared with the US response to the H1N1 (swine) flu outbreak. We analyze the latest developments and examine what things we can learn from the present situation and what might be done to combat the threat. The lessons may only be valid for a few months if major changes (e.g., vaccine technology and availability, antiviral stockpile size, antiviral resistance) occur, but some of the parameters can still help guide pandemic planning measures and will continue to have relevance.
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  • Emerging infectious diseases 03/2011; DOI:10.3201/eid1703100581 · 7.33 Impact Factor

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