Sarcomatoid carcinoma of the thymus arising in metaplastic thymoma

Histopathology (Impact Factor: 3.45). 03/2008; 52(3):409-11. DOI: 10.1111/j.1365-2559.2007.02960.x
Source: PubMed
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    • "MT differs from SC in showing good circumscription and bland-looking spindle cells, even though squamoid epithelial islands may show nuclear polymorphism.4,5 Recently, 2 cases of SC arising in MT have been reported.8,9 The tumors had foci with marked atypical spindle cells, frequent mitotic figures and necrosis, but the follow-up was too short to assess behavior. "
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    ABSTRACT: Metaplastic thymoma (MT), accepted in the World Health Organization 2004 scheme, is a circumscribed tumor of the thymus exhibiting biphasic morphology. We herein describe the clinicopathologic features of four MTs and the differential diagnoses of this unusual tumor. There were three women and one man with mean age of 49.5 years. The patients were found to have mediastinal masses, and underwent surgical excision. One exhibited symptoms of myasthenia gravis, and the serum titer for anti-acetylcholine receptor antibody was positive. Grossly, the tumors were encapsulated, and showed vaguely multinodular, solid, tan-white to yellow cut surfaces. Histologically, they comprised epithelial islands intertwining with bundles of delicate spindle cells. The patients remained well after surgical excision at 5-55 months. Because of the distinctive histological appearance and benign clinical course, MT should be distinguished from other more aggressive mediastinal neoplasms displaying biphasic feature.
    02/2012; 46(1):92-5. DOI:10.4132/KoreanJPathol.2012.46.1.92

  • Haigan 06/2010; 50(3):322-323. DOI:10.2482/haigan.50.322
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    ABSTRACT: Metaplastic thymoma is an extremely rare tumor. To date, only 17 cases of metaplastic thymoma have been reported. To the best of the authors' knowledge, this is the second reported case of a sarcomatoid carcinoma arising in metaplastic thymoma; the carcinoma in this case is larger than that in the previous case. A 63-year-old woman with cough and asthenia for 2 weeks was admitted to the hospital. Computed tomography (CT) revealed a giant mass on the right side of the front mediastinum medium. The mediastinal tumor was excised, and additional pathological examinations, immunohistochemical tests, and electron-microscopic tests were performed. The tumor was diagnosed as a sarcomatoid carcinoma arising in metaplastic thymoma. Here, the authors discuss the clinical pathology of the sarcomatoid carcinoma arising in metaplastic thymoma and describe the biological behaviors with respect to the pathological features.
    International Journal of Surgical Pathology 10/2011; 19(5):677-80. DOI:10.1177/1066896909355458 · 0.95 Impact Factor
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