Article

Comparative expression of calretinin in selected odontogenic tumours: a possible relationship to histogenesis.

Dental Research Centre, Faculty of Dentistry, Medical Sciences/University of Tehran, Tehran, Iran.
Histopathology (impact factor: 3.08). 02/2008; 52(3):299-304. DOI:10.1111/j.1365-2559.2007.02948.x
Source: PubMed

ABSTRACT Calretinin, a calcium-binding protein, is expressed primarily in certain subtypes of neurons. It has also been reported to be present in mesotheliomas and other tumours. The aim was to determine the expression of calretinin in selected odontogenic neoplasms.
Immunohistochemistry for calretinin was performed on 55 odontogenic tumours consisting of 20 solid ameloblastomas, five calcifying epithelial odontogenic tumours, 10 adenomatoid odontogenic tumours, 10 ameloblastic fibromas and 10 odontogenic myxomas. The distribution, intensity, pattern and localization of immunoreactive cells were determined by conventional light microscopy. chi(2) test was used for statistical analysis and P < 0.05 was considered to be significant. All 20 ameloblastomas showed intense immunopositivity with a diffuse distribution pattern. None of the other neoplasms was reactive with calretinin. Differences in the proportion of calretinin expression between groups were statistically significant at P < 0.001.
Considering that ameloblastomas, in contrast to the other studied tumours, were consistently reactive for calretinin, this protein may have a role in the pathogenesis of this aggressive neoplasm.

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Keywords

10 adenomatoid odontogenic tumours
 
10 ameloblastic fibromas
 
10 odontogenic myxomas
 
20 ameloblastomas
 
20 solid ameloblastomas
 
55 odontogenic tumours
 
aggressive neoplasm
 
calcifying epithelial odontogenic tumours
 
calcium-binding protein
 
Calretinin
 
calretinin expression
 
certain subtypes
 
Differences
 
immunoreactive cells
 
intense immunopositivity
 
mesotheliomas
 
neoplasms
 
odontogenic neoplasms
 
statistical analysis
 
studied tumours