DNA repair dysfunction in gastrointestinal tract cancers.

Abstract

The DNA repair system surveys the genome, which is always suffering from exposure to both exogenous as well as endogenous mutagens, to maintain the genetic information. The fact that the basis of this DNA repair system is highly conserved, from prokaryote to mammalian cells, suggests the importance of precise genome maintenance mechanisms for organisms. In the past 15 years, considerable progress has been made in understanding how repair processes interact and how disruptions of these mechanisms lead to the accumulation of mutations and carcinogenesis. In 1993, two groups reported that DNA mismatch repair could be associated with hereditary non-polyposis colorectal cancer, indicating a connection between faulty DNA repair function and cancer. More recently, an inherited disorder of DNA glycosylase, which removes mutagenic oxidized base from DNA, has been reported in individuals with a predisposition to multiple colorectal adenomas and carcinomas. This is the first report that directly indicates the role of the repair of oxidative DNA in human inherited cancer. Studies from gene knockout mice have elucidated the principal role of these repair systems in the process of carcinogenesis. Moreover, clinical samples derived from cancer patients have shown the direct involvement. This review focuses on the function of DNA mismatch repair and oxidative DNA/nucleotide repair among various DNA repair systems in cells, both of which are essentially involved in the carcinogenesis of gastrointestinal tract cancer.

Full text

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九州大学大学院九州大学大学院 消化器・総合外科（第二外科） 消化器・総合外科（第二外科）
200 2008 8年発表論文 年発表論文
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1
DNA repair dysfunction in gastrointestinal tract cancers.
Cancer Sci. 99(3):451-458,2008
2 New technique for the retraction of the liver in laparoscopic gastrectomy.
Sakaguchi Y, Ikeda O, Toh Y, Aoki Y, Harimoto N, Taomoto J, Masuda T, Ohga T, Adachi E, Okamura T.
Surg. Endosc. 22(11):2532-2534,2008
3 Phase II study of weekly paclitaxel by one-hour infusion for advanced gastric cancer.
Surg. Today 38(11):1013-1020,2008
4 Esophagectomy in patients 80 years of age and older with carcinoma of the thoracic esophagus.
Morita M, Egashira A, Yoshida R, Ikeda K, Ohgaki K, Shibahara K, Oki E, Sadanaga N, Kakeji Y, Maehara Y..
J. Gastroenterol. 43(5):345-351,2008
5
Acute lung injury following an esophagectomy for esophageal cancer, with special reference to the clinical factors and cytokine
levels of peripheral blood and pleural drainage fluid.
Morita M, Yoshida R, Ikeda K, Egashira A, Oki E, Sadanaga N, Kakeji Y, Ichiki Y, Sugio K, Yasumoto K, Maehara Y.
Dis Esophagus 21(1):30-36,2008
6 Advances in esophageal cancer surgery in Japan: an analysis of 1000 consecutive patients treated at a single institute.
Morita M, Yoshida R, Ikeda K, Egashira A, Oki E, Sadanaga N, Kakeji Y, Yamanaka T, Maehara Y. .
Surgery 143(4):499-508,2008
7
Cecal volvulus in cerebral palsy: report of a case.
Takeuchi H, Ikeda Y, Komori Y, Tahara K, Shiromizu A, Hayashi H, Muto Y.
Surg. Today 38(2):170-173,2008
Emi Y, Yamamoto M, Takahashi I, Orita H, Kakeji Y, Kohnoe S, Maehara Y.
Maehara Y, Egashira A, Oki E, Kakeji Y, Tsuzuki T.
8
The postoperative recurrence and the occurrence of second primary carcinomas.in patients with early gastric carcinoma.
Yamamoto M, Yamanaka T, Baba H, Kakeji Y, Maehara Y.
J. Surg. Oncol. 97(3):231-235,2008
9
Adenocarcinoma of the esophagogastric junction in Japan.
Yamamoto M, Baba H, Egashira A, Oki E, Ikebe M, Kakeji Y, Maehara Y.
Hepato-Gastroenterol. 55(81):103-107,2008
消化管消化管

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九州大学大学院九州大学大学院 消化器・総合外科（第二外科） 消化器・総合外科（第二外科）
200 2008 8年発表論文 年発表論文
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10 Preoperative elevation of serum C-reactive protein as an independent prognostic indicator of colorectal carcinoma.
Nozoe T, Mori E, Takahashi I, Ezaki T.
Surg. Today 38(7):597-602,2008
Podoplanin: a novel marker for oral cancer risk in patients with oral premalignancy.
Kawaguchi H, El-Naggar AK, Papadimitrakopoulou V, Ren H, Fan YH, Feng L, Lee JJ, Kim E, Hong WK, Lippman SM, Mao L.
J. Clin. Oncol. 26(3):354-360,2008
1
Detection of circulating gastric cancer cells in peripheral blood using real time quantitative RT-PCR.
Koga T, Tokunaga E, Sumiyoshi Y, Oki E, Oda S, Takahashi I, Kakeji Y, Baba H, Maehara Y.
Hepato-Gastroenterol. 55(84):1131-1135,2008
1
Successful treatment of tracheomediastinal fistula after tracheal injury obtained during esophagectomy using the pectoralis major muscle:
3 a case report.
Koga T, Morita M, Nishida K, Oki E, Kakeji Y, Maehara Y.
Esophagus 5:41-44,2008
14 Activin A enhances MMP-7 activity via the transcription factor AP-1 in an esophageal squamous cell carcinoma cell line.
Yoshinaga K, Mimori K, Inoue H, Kamohara Y, Yamashita K, Tanaka F, Mori M.
Int. J. Oncol. 33(3):453-459,2008
15 Clinical characteristics of gastric cancer with metastasis to the lymph node along the superior mesenteric vein (14v).
Masuda TA, Sakaguchi Y, Toh Y, Aoki Y, Harimoto N, Taomoto J, Ikeda O, Ohga T, Adachi E, Okamura T.
Dig. Surg. 25(5):351-358,2008
11
2
16 Clinical characteristics of lower bowel perforation with chronic renal failure.
Masuda TA, Iso Y, Funahashi S, Tateishi M, Shima I, Kido A, Gohya T, Masuda H.
Hepato-Gastroenterol. 55(86-87):1640-1644,2008
17 Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer.
Ohta M, Mimori K, Fukuyoshi Y, Kita Y, Motoyama K, Yamashita K, Ishii H, Inoue H, Mori M.
Br. J. Cancer 98(2):410-417,2008
18 Genetic polymorphisms of cyclooxygenase-2 and colorectal adenoma risk: The self defense forces health study.
Ueda N, Maehara Y, Tajima O, Tabata S, Wakabayashi K, Kono S.
Cancer Sci. 99(3):576-581,2008
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九州大学大学院九州大学大学院 消化器・総合外科（第二外科）消化器・総合外科（第二外科）
200 2008 8年発表論文年発表論文
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Regulation of histone H4 acetylation by transcription factor E2A in Ig gene conversion.
Kitao H, Kimura M, Yamamoto K, Seo H, Namikoshi K, Agata Y, Ohta K, Takata M.
Int. Immunol. 20(2):277-284,2008
19
消化管消化管
FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway.
Ishiai M, Kitao H, Smogorzewska A, Tomida J, Kinomura A, Uchida E, Saberi A, Kinoshita E, Kinoshita-Kikuta E, Koike T, Tashiro S,
Elledge SJ, Takata M.
Nat. Struct. Mol. Biol. 15(11):1138-1146,2008
20

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九州大学大学院九州大学大学院 消化器・総合外科（第二外科）消化器・総合外科（第二外科）
2002008 8年発表論文年発表論文
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Clinical characteristics of small cell carcinoma of the breast.
Sadanaga N, Okada S, Shiotani S, Morita M, Kakeji Y, Kitamura K, Tamiya S, Sugimachi K, Maehara Y.
Oncol. Rep. 19(4):981-985,2008
21
乳　腺乳　腺
Curr. Cancer Drug Targets 8(1):27-36,2008
22 Deregulation of the akt pathway in human cancer.
Tokunaga E, Oki E, Egashira A, Sadanaga N, Morita M, Kakeji Y, Maehara Y.

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九州大学大学院九州大学大学院 消化器・総合外科（第二外科）消化器・総合外科（第二外科）
2002008 8年発表論文年発表論文
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23 Secondary c-kit mutation in a recurrent gastrointestinal stromal tumor under long-term treatment with imatinib mesylate:
report of a case.
Utsunomiya T, Okamoto M, Yano S, Kameyama T, Matsuyama A, Kuma S, Yamamoto M, Fujiwara M, Ishida T.
Surg. Today.38(1):65-67,2008
Impact of obesity on the surgical outcome following repeat hepatic resection in Japanese patients with recurrent hepatocellular carcinoma.
Utsunomiya T, Okamoto M, Kameyama T, Matsuyama A, Yamamoto M, Fujiwara M, Mori M, Aimitsu S, Ishida T.
World J. Gastroenterol. 14(10):1553-1558,2008
25 Prognosis of early hepatocellular carcinoma after hepatic resection.
Maeda T, Shimada M, Harimoto N, Tsujita E, Aishima S, Tanaka S, Shirabe K, Maehara Y.
Hepato-Gastroenterol. 55(85):1428-1432,2008
26
Surgically resected hepatocellular carcinomas in patients with non-alcoholic steatohepatitis.
Maeda T, Hashimoto K, Kihara Y, Ikegami T, Ishida T, Aimitsu S, Fujiwara M.
Hepato-Gastroenterol. 55(85):1404-1406,2008
27 Liver transplantation for hepatocellular carcinoma.
Taketomi A, Soejima Y, Yoshizumi T, Uchiyama H, Yamashita Y, Maehara Y.
J. Hepatobiliary Pancreatic Surg. 15(2):124-130,2008
28
The impact of surgical treatment and poor prognostic factors for patients with intrahepatic cholangiocarcinoma:
retrospective analysis of 60 patients.
Yamashita Y, Taketomi A, Morita K, Fukuhara T, Ueda S, Sanefuji K, Iguchi T, Kayashima H, Sugimachi K, Maehara Y.
Anticancer Res. 28(4C):2353-2359,2008
24

29 Biliary neoplasia with extensive intraductal spread associated with liver cirrhosis:
a hitherto unreported variant of biliary intraepithelial neoplasia.
Aishima S, Nishihara Y, Tsujita E, Taguchi K, Soejima Y, Taketomi A, Ikeda Y, Maehara Y, Tsuneyoshi M.
Hum. Pathol. 39(6):939-947,2008
30 Lymphatic spread is related to VEGF-C expression and D2-40-positive myofibroblasts in intrahepatic cholangiocarcinoma.
Aishima S, Nishihara Y, Iguchi T, Taguchi K, Taketomi A, Maehara Y, Tsuneyoshi M.
Mod. Pathol. 21(3):256-264,2008
31 Factors influencing the development of small intestinal obstruction following gastrectomy for early gastric cancer.
Sugimachi K, Korenaga D, Tomikawa M, Ikeda Y, Tsukamoto S, Kawasaki K, Yamamura S, Takenaka K.
Hepato-Gastroenterol. 55(82-83):496-499,2008
肝臓・移植肝臓・移植 　　

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九州大学大学院九州大学大学院 消化器・総合外科（第二外科）消化器・総合外科（第二外科）
2002008 8年発表論文年発表論文
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32 Appraisal of hepatic resection in the treatment of hepatocellular carcinoma with severe thrombocytopenia.
Sugimachi K, Ikeda Y, Tomikawa M, Taketomi A, Tsukamoto S, Kawasaki K, Yamamura S, Korenaga D, Maehara Y, Takenaka K.
World J. Surg. 32(6):1077-1081,2008
肝臓・移植肝臓・移植 　　
33 Extended hemi-hepatectomy with portal vein reconstruction in a patient with situs ambiguous.
Sugimachi K, Ikeda Y, Taketomi A, Tomikawa M, Kawasaki K, Korenaga D, Maehara Y, Takenaka K.
Case Rep. Gastroenterol. 2:76-82,2008
34 Recurrence of intrahepatic cholangiocarcinoma nine years after surgical resection.
Kitagawa D, Taketomi A, Aishima S, Kuroda Y, Gion T, Shirabe K, Shimada M, Maehara Y.
Hepato-Gastroenterol. 55(84):1085-1088,2008
35 Liver metastasis with intraductal invasion originating from rectal cancer: Report of a case.
Kayashima H, Taketomi A, Yamashita Y, Kuroda Y, Kitagawa D, Harimoto N, Tsujita E, Maehara Y.
Surg. Today 38(8):765-768,2008
36 Accuracy of an age-adjusted formula in assessing the graft volume in living donor liver transplantation.
Kayashima H, Taketomi A, Yonemura Y, Ijichi H, Harada N, Yoshizumi T, Soejima Y, Yoshimitsu K, Maehara Y.
Liver Transplant. 14(9):1366-1371,2008
37 Extracapsular penetration is a new prognostic factor in human hepatocellular carcinoma.
Iguchi T, Aishima S, Taketomi A, Nishihara Y, Fujita N, Sanefuji K, Maehara Y, Tsuneyoshi M.
Am. J. Surg. Pathol. 32(11):1675-1682,2008
38 Is an elderly recipient a risk for living donor adult liver transplantation?
Suehiro T, Shimada M, Kishikawa K, Shimura T, Soejima Y, Yoshizumi T, Hashimoto K, Mochida Y, Maehara Y, Kuwano H.
Hepato-Gastroenterol. 55(82-83):653-656,2008
39 The effect of hyperbaric oxygen treatment on postoperative morbidity of left lobe donor in living donor adult liver transplantation.
Suehiro T, Shimura T, Okamura K, Okada T, Okada K, Hashimoto S, Mochida Y, Kuwano H, Saitoh S, Gotoh F.
Hepato-Gastroenterol. 55(84):1014-1019,2008
40 Prolonged antibiotic prophylaxis longer than 24 hours does not decrease surgical site infection after elective gastric and colorectal surgery.
Suehiro T, Hirashita T, Araki S, Matsumata T, Tsutsumi S, Mochiki E, Kato H, Asao T, Kuwano H.
Hepato-Gastroenterol. 55(86-87):1636-1639,2008

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九州大学大学院九州大学大学院 消化器・総合外科（第二外科）消化器・総合外科（第二外科）
2002008 8年発表論文年発表論文
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41 Left lobe living donor liver transplantation in an adult patient with situs inversus: technical considerations.
肝臓・移植肝臓・移植 　　
42 Living donor liver transplantation using dual grafts from two donors: a feasible option to overcome small-for-size graft problems?
Soejima Y, Taketomi A, Ikegami T, Yoshizumi T, Uchiyama H, Yamashita Y, Meguro M, Harada N, Shimada M, Maehara Y.
Am. J. Transplant. 8(4):887-892,2008
43 One-step venous reconstruction for a right lobe graft with multiple venous orifices in living donor liver transplantation.
Soejima Y, Ueda N, Fukuhara T, Yoshizumi T, Ikegami T, Yamashita Y, Sugimachi K, Taketomi A, Maehara Y.
Liver Transplant. 14(5):706-708,2008
44 Sequential pancreaticoduodenectomy after living donor liver transplantation for cholangiocarcinoma.
Soejima Y, Ueda S, Sanefuji K, Kayashima H, Yoshizumi T, Ikegami T, Yamashita Y, Sugimachi K, Iguchi T, Taketomi A, Maehara Y.
Am. J. Transplant.8(10):2158-2162,2008
45 A simple hilar dissection technique preserving maximum blood supply to the bile duct in living donor liver transplantation.
Soejima Y, Fukuhara T, Morita K, Yoshizumi T, Ikegami T, Yamashita Y, Sugimachi K, Taketomi A, Maehara Y.
Transplantation 86(10):1468-1469,2008
46 Graft size, donor age, and patient status are the indicators of early graft function after living donor liver transplantation.
Yoshizumi T, Taketomi A, Uchiyama H, Harada N, Kayashima H, Yamashita Y, Soejima Y, Shimada M, Maehara Y.
Liver Transplant. 14(7):1007-1013,2008
47 The beneficial role of simultaneous splenectomy in living donor liver transplantation in patients with small-for-size graft.
Yoshizumi T, Taketomi A, Soejima Y, Ikegami T, Uchiyama H, Kayashima H, Harada N, Yamashita Y, Kawanaka H, Nishizak T, Maehara Y.
Transpl. Int.21(9):833-842,2008
48 Impact of donor age and recipient status on left-lobe graft for living donor adult liver transplantation.
Yoshizumi T, Taketomi A, Soejima Y, Uchiyama H, Ikegami T, Harada N, Kayashima H, Yamashita Y, Shimada M, Maehara Y.
Transpl. Int. 21(1):81-88,2008
49 Estimation of standard liver volume for Japanese adults.
Yoshizumi T, Taketomi A, Kayashima H, Yonemura Y, Harada N, Ijichi H, Soejima Y, Nishizaki T, Maehara Y.
Transplant. Proc. 40(5):1456-1460,2008
Soejima Y, Meguro M, Taketomi A, Ikegami T, Yamashita Y, Harada N, Ito S, Uchiyama H, Yoshizumi T, Maehara Y.
Transpl. Int. 21(4):384-389,2008

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九州大学大学院九州大学大学院 消化器・総合外科（第二外科）消化器・総合外科（第二外科）
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50 Successful treatment for a patient with hemophagocytic syndrome after a small-for-size graft liver transplantation.
肝臓・移植肝臓・移植 　　
51 The use of marginal grafts in liver transplantation.
Hashimoto K, Miller C.
J. Hepatobiliary Pancreatic Surg. 15(2):92-101,2008
52
Ikegami T, Shimada M, Imura S, Yoshizumi T, Arakawa Y, Tokunaga T, Morine Y, Kanemura H.
Transplantation 86(5):641-646,2008
53 Extracorporeal hepatic resection for unresectable giant hepatic hemangiomas.
Ikegami T, Soejima Y, Taketomi A, Kayashima H, Sanefuji K, Yoshizumi T, Harada N, Yamashita Y, Maehara Y.
Liver Transplant. 14(1):115-117,2008
54 Transient portocaval shunt for a small-for-size graft in living donor liver transplantation.
Ikegami T, Imura S, Arakawa Y, Shimada M.
Transplant. 14(2):262,2008
55 Living donor liver transplantation for acute liver failure: A 10-year experience in a single center.
Ikegami T, Taketomi A, Soejima Y, Yoshizumi T, Sanefuji K, Kayashima H, Shimada M, Maehara Y.
J. Am. Coll. Surg. 206(3):412-418,2008
56 Hilar anatomical variations in living-donor liver transplantation using right-lobe grafts.
Ikegami T, Soejima Y, Taketomi A, Yoshizumi T, Harada N, Kayashima H, Itoh S, Yamashita Y, Maehara Y.
Dig. Surg. 25(2):117-123,2008
57 Living donor liver transplantation for acute liver failure using left lobe grafts.
Ikegami T, Taketomi A, Soejima Y, Yoshizumi T, Maehara Y.
Transplantation 85(1):160-161,2008
58 Meso-systemic shunt for middle hepatic vein reconstruction in right lobe living donor liver transplantation.
Ikegami T, Soejima Y, Taketomi A, Kayashima H, Maehara Y.
Transpl. Int. 21(1):94-95,2008
Yoshizumi T, Taketomi A, Kayashima H, Harada N, Uchiyama H, Yamashita Y, Ikegami T, Soejima Y, Nishizaki T, Shimada M,
Maehara Y.
Hepato-Gastroenterol. 55(82-83):359-362,2008
The timing of liver transplantation after primary hepatectomy for hepatocellular carcinoma:special reference to recurrence pattern
and Milan criteria.

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九州大学大学院九州大学大学院 消化器・総合外科（第二外科）消化器・総合外科（第二外科）
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　　 肝臓・移植肝臓・移植 　　
59 Living donor liver transplantation for fulminant hepatic failure from ABO-incompatible donors.
60 Donor age in living donor liver transplantation.
Ikegami T, Taketomi A, Ohta R, Soejima Y, Yoshizumi T, Shimada M, Maehara Y.
Transplant. Proc. 40(5):1471-1475,2008
Ikegami T, Sanchez EQ, Uemura T, Narasimhan G, Masannat O, Chinnakotla S, McKenna GJ, Randall HB, Levy MF, Goldstein RM,
Klintmalm GB.
Surg. Today 38(1):26-29,2008
62 Characteristics of biliary reconstruction using a T-tube as compared with other methods in left-lobe adult living-donor liver transplantation.
Ikegami T, Taketomi A, Soejima Y, Yoshizumi T, Shimada M, Maehara Y.
J. Hepatobiliary Pancreatic Surg. 15(3):346-347,2008
63 Biliary reconstruction in right lobe living donor liver transplantation.
Ikegami T, Imura S, Morine Y, Mori H, Shimada M.
Hepatology Res. 38(10):1058-1060,2008
64 Living donor liver transplantation with extra-small graft; inflow modulation using splenectomy and temporary portocaval shunt.
Ikegami T, Soejima Y, Taketomi A, Sanefuji K, Kayashima H, Harada N, Yamashita Y, Maehara Y.
Hepato-Gastroenterol. 55(82-83):670-672,2008
65 Living donor liver transplantation for hepatitis B associated liver diseases: A 10-year experience in a single center.
Ikegami T, Soejima Y, Ohta R, Taketomi A, Yoshizumi T, Harada N, Kayashima H, Maehara Y.
Hepato-Gastroenterol. 55(85):1445-1449,2008
66
Ikegami T, Soejima Y, Taketomi A, Harada N, Uehara H, Yamashita Y, Maehara Y.
Surg. Today 38(6):576-577,2008
67 Recent role of splenectomy in chronic hepatic disorders.
Ikegami T, Shimada M, Imura S.
Hepatology Res. 38(12):1159-1171,2008
Ikegami T, Soejima Y, Taketomi A, Yoshizumi T, Maehara Y.
Transpl. Int. 21(3):284-285,2008
Liver transplantation for cystic fibrosis in adults.
61
Small-intestinal volvulus around the superior mesenteric artery as an extremely rare positioning-associated complication after
percutaneous liver biopsy.

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68 Current concept of small-for-size grafts in living donor liver transplantation.
Ikegami T, Shimada M, Imura S, Arakawa Y, Nii A, Morine Y, Kanemura H.
Surg. Today 38(11):971-982,2008
69 Beneficial use of the round ligament as a patch graft for vena cava reconstruction.
Ikegami T, Shimada M, Imura S, Morine Y, Kanemura H, Mori H, Arakawa Y, Hanaoka J.
J. Hepatobiliary Pancreatic Surg. 15(6):581-584,2008
70 Adenomatoid tumour of the liver.
Nagata S, Aishima S, Fukuzawa K, Takagi H, Yonemasu H, Iwashita Y, Kinoshita T, Wakasugi K.
J. Clin. Pathol. 61(6):777-780,2008
71 Adult-to-adult living donor liver transplantation in severe portosystemic shunt cases.
Nagata S, Shimada M, Soejima Y, Nishizaki T, Yoshizumi T, Maehara Y.
Hepato-Gastroenterol. 55(82-83):666-669,2008
72 Assessment of graft fibrosis by transient elastography in patients with recurrent hepatitis C after living donor liver transplantation
- Response to Letter.
Harada N.
Transplantation 86(5):749,2008
73 Assessment of graft fibrosis by transient elastography in patients with recurrent hepatitis C after living donor liver transplantation.
Harada N, Soejima Y, Taketomi A, Yoshizumi T, Ikegami T, Yamashita Y, Itoh S, Kuroda Y, Maehara Y.
Transplantation 85(1):69-74,2008
74 Stenotrophomonas maltophilia bacteremia after living donor liver transplantation: report of a case.
Harada N, Soejima Y, Taketomi A, Yoshizumi T, Uchiyama H, Maehara Y.
Surg. Today 38(5):469-472,2008
75 Successful management of chylous ascites after living donor liver transplantation with somatostatin.
Harada N, Soejima Y, Taketomi A, Yoshizumi T, Uchiyama H, Maehara Y.
Ijichi H, Soejima Y, Taketomi A, Yoshizumi T, Uchiyama H, Harada N, Yonemura Y, Maehara Y.

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脾・ 門脈脾・ 門脈 　　　　pagepage1 11 1
76Long-term results of balloon-occluded retrograde transvenous obliteration for gastric variceal bleeding and risky gastric varices:
A 10-year experience.
J. Gastroenterol. Hepatol. 23(11):1702-1709,2008
ANZ J Surg. 78(3):219,2008
78 Significance of ERK nitration in portal hypertensive gastropathy and its therapeutic implications.
Am. J. Physiol.-Gastroint. Liver Physiol. 295(5):1016-1024,2008
Kinjo N, Kawanaka H, Akahoshi T, Yamaguchi S, Yoshida D, Anegawa G, Konishi K, Tomikawa M, Tanoue K, Tarnawski A,
Hashizume M, Maehara Y.
Akahoshi T, Hashizume M, Tomikawa M, Kawanaka H, Yamaguchi S, Konishi K, Kinjo N, Maehara Y.
Giant inguinal hernia containing right colon repaired using the prolene hernia system.

Tsutsumi N, Guntani A, Rikimaru T, Watanabe A, Kohnoe S.
77
79 Defective endothelial nitric oxide synthase signaling is mediated by rho-kinase activation in rats with secondary biliary cirrhosis.
Anegawa G, Kawanaka H, Yoshida D, Konishi K, Yamaguchi S, Kinjo N, Taketomi A, Hashizume M, Shimokawa H, Maehara Y.
Hepatology 47(3):966-977,2008

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肺　　　　　　肺
J. Clin. Oncol. 26(26):4244-4252,2008
Suemitsu R, Maruyama R, Nishiyama K, Okamoto T, Wataya H, Seto T, Ichinose Y.
Ann. Thorac. Cardiovasc. Surg. 14(2):109-111,2008
86

Suemitsu R, Yamaguchi M, Takeo S, Ondo K, Ueda H, Yoshino I, Maehara Y.
Ann. Thorac. Cardiovasc. Surg. 14(3):154-160,2008
87 Resection of mediastinal granulocytic sarcoma triggered the rapid progression of acute myeloid leukemia.
Suemitsu R, Fukuyama S, Ondo K, Ueda H.
Ann. Thorac. Cardiovasc. Surg.14(3):181-183,2008
88 Dumbbell-shaped mediastinal neurogenic tumor forming a string-of-beads structure.
Suemitsu R, Matsuzawa H, Yamaguchi M, Takeo S.
J. Thorac. Cardiovasc. Surg. 136(2):522-523,2008
82
Feasibility trial of adjuvant chemotherapy with paclitaxel and carboplatin after surgical resection in Japanese patients with non-small
cell lung cancer:rreport of the Lung Oncology Group in Kyushu (LOGIK) protocol 0501.
Maruyama R, Yoshino I, Tokunaga S, Ohta M, Kato M, Yoshimine H, Yamazaki K, Nakanishi Y, Ichinose Y.
Gen. Thorac. Cardiovasc. Surg. 56(2):68-73,2008
80
81
83
Intratumoral expression of macrophage migration inhibitory factor is correlated with serum C-reactive protein and interleukin-6
in patients with non-small cell lung cancer.
Hamatake M, Yoshino I, Tomiyasu M, Miura N, Okazaki H, Ohba T, Takenaka T, Maehara Y.
Surg. Today 38(10): 921-925,2008
Yano T, Miura N, Takenaka T, Haro A, Okazaki H, Ohba T, Kouso H, Kometani T, Shoji F, Maehara Y.
Phase III study, V-15-32, of gefitinib versus docetaxel in previously treated Japanese patients with non-small-cell lung cancer.
Cancer 113(5):1012-1018,2008
Maruyama R, Nishiwaki Y, Tamura T, Yamamoto N, Tsuboi M, Nakagawa K, Shinkai T, Negoro S, Imamura F, Eguchi K, Takeda K,
Inoue A, Tomii K, Harada M, Masuda N, Jiang H, Itoh Y, Ichinose Y, Saijo N, Fukuoka M.
Never-smoking nonsmall cell lung cancer as a separate entity: clinicopathologic features and survival.
Eur. J. Surg. Oncol. 34(1):89-93,2008
84 The characteristics and failure pattern of gefitinib responders with postoperative recurrence of pulmonary adenocarcinoma.
Shoji F, Yano T, Yoshino I, Mori D, Yamasaki F, Kohno H, Maehara Y.
85 Pulmonary typical carcinoid tumor and liver metastasis with hypermetabolism on 18-fluorodeoxyglucose PET: a case report.
Favorable surgical results for patients with nonsmall cell lung cancer over 80 years old: a multicenter survey.

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89 Effect of body mass index on perioperative complications in thoracic surgery.
Suemitsu R, Sakoguchi T, Morikawa K, Yamaguchi M, Tanaka H, Takeo S.
Asian Cardiovasc. Thorac. Ann. 16(6):463-467,2008
90 Resection of radiation-induced sarcoma of the clavicle.
Osoegawa A, Yoshino I, Yamaguchi M, Kameyama T, Kometani T, Kumamoto Y, Maehara Y.
Ann. Thorac. Cardiovasc. Surg. 14(3):178-180,2008
91 Expression of mismatch repair proteins, hMLH1/hMSH2, in non-small cell lung cancer tissues and its clinical significance.
Kouso H, Yoshino I, Miura N, Takenaka T, Ohba T, Yohena T, Osoegawa A, Shoji F, Maehara Y.
J. Surg. Oncol. 98(5):377-383,2008
92Schwannoma in the peridiaphragm.
Ohba T, Shoji F, Kometani T, Yoshino I, Maehara Y.
Gen. Thorac. Cardiovasc. Surg. 56(9):453-455,2008
93 Extraskeletal osteosarcoma of the pleura: a case report.
Matono R, Maruyama R, Ide S, Kitagawa D, Tanaka J, Saeki H, Shimokama T, Higashi H.
Gen. Thorac. Cardiovasc. Surg. 56(4):180-182,2008
肺肺　　　　　　

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94 Immunostimulatory virotherapy using recombinant Sendai virus as a new cancer therapeutic regimen.
Yonemitsu Y, Ueda Y, Kinoh H, Hasegawa M.
Front. Biosci. 13:1892-1898,2008
95 Leiomyosarcoma originating from the superior mesenteric vein: a case report and review of the literature.
Kuma S, Utsunomiya T, Yano S, Kameyama T, Okamoto M, Matsuyama A, Hashimoto K, Yamamoto M, Ezaki T, Fujihara M, Ishida T..
Ann. Vasc. Surg. 22(3):453-455,2008
96 Treatment of solitary iliac aneurysms: clinical review of 28 cases.
Hu H, Takano T, Guntani A, Onohara T, Furuyama T, Inoguchi H, Takai M, Maehara Y.
Surg. Today 38(3):232-236,2008