Soy isoflavones in the management of postmenopausal osteoporosis.
ABSTRACT This is a review article designed to address the effects of soy isoflavones on bone metabolism in postmenopausal women and their place in the prevention and treatment of postmenopausal osteoporosis. Soy isoflavones are natural products that could be used as an alternative to menopausal hormone therapy because they are structurally and functionally related to 17beta-estradiol. In vitro and animal studies have shown that they act in multiple ways to exert their bone-supporting effects. They act on both osteoblasts and osteoclasts through genomic and nongenomic pathways. Epidemiological studies and clinical trials suggest that soy isoflavones have beneficial effects on bone mineral density, bone turnover markers, and bone mechanical strength in postmenopausal women. However, there are conflicting results related to differences in study design, estrogen status of the body, metabolism of isoflavones among individuals, and other dietary factors. The long-term safety of soy isoflavone supplements remains to be demonstrated.
SourceAvailable from: N G Edwin Oliver
Article: Antioxidants and Human Diseases.[Show abstract] [Hide abstract]
ABSTRACT: Oxidative stress plays a pivotal role in the development of human diseases. Reactive oxygen species (ROS) that includes hydrogen peroxide, hyphochlorus acid, superoxide anion, singlet oxygen, lipid peroxides, hypochlorite and hydroxyl radical are involved in growth, differentiation, progression and death of the cell. They can react with membrane lipids, nucleic acids, proteins, enzymes and other small molecules. Low concentrations of ROS has an indispensable role in intracellular signalling and defence against pathogens, while, higher amounts of ROS play a role in number of human diseases, including arthritis, cancer, diabetes, atherosclerosis, ischemia, failures in immunity and endocrine functions. Antioxidants presumably act as safeguard against the accumulation of ROS and their elimination from the system. The aim of this review is to highlight advances in understanding of the ROS and also to summarize the detailed impact and involvement of antioxidants in selected human diseases.Clinica Chimica Acta 06/2014; 436(25):332-347. DOI:10.1016/j.cca.2014.06.004 · 2.76 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Isoflavones are the most abundant phytoestrogen in soybeans which are structurally similar with 17 β-estradiol. The antioxidant property of genistein and daidzein are well established in different experimental and clinical models. Isoflavones compounds have been found effective in the management of diabetes. It reduces low-density lipoprotein and triglycerides and hence minimizes the risk of coronary heart disease. Soy isoflavones was found useful for treatment of osteoporosis by inhibiting tyrosine kinase. In soy isoflavones, genistein is effective in the treatment of cancer by acting on androgen receptor and inhibiting tyrosine kinases. In this update many nutraceuitical and medicinal uses and applications of soy isoflavones have been investigated such as treatment and prevention of cardiovascular diseases, cholesterol lowering, osteoporosis, diabetes, cancer, cognitive decline, and menopausal symptoms.
[Show abstract] [Hide abstract]
ABSTRACT: In the present work, a detailed conformational study of cladrin (3-(3,4-dimethoxy phenyl)-7-hydroxychromen-4-one) has been done by using spectroscopic techniques (FT-IR/FT-Raman/UV-Vis/NMR) and quantum chemical calculations. The optimized geometry, wavenumber and intensity of the vibrational bands of the cladrin in ground state were calculated by density functional theory (DFT) employing 6-311++G(d,p) basis sets. The study has been focused on the two most stable conformers that are selected after the full geometry optimization of the molecule. A detailed assignment of the FT-IR and FT-Raman spectra has been done for both the conformers along with potential energy distribution for each vibrational mode. The observed and scaled wavenumber of most of the bands has been found to be in good agreement. The UV-Vis spectrum has been recorded and compared with calculated spectrum. In addition, (1)H and (13)C nuclear magnetic resonance spectra have been also recorded and compared with the calculated data that shows the inter or intramolecular hydrogen bonding. The electronic properties such as HOMO-LUMO energies were calculated by using time-dependent density functional theory. Molecular electrostatic potential has been plotted to elucidate the reactive part of the molecule. Natural bond orbital analysis was performed to investigate the molecular stability. Non linear optical property of the molecule have been studied by calculating the electric dipole moment (μ) and the first hyperpolarizability (β) that results in the nonlinearity of the molecule.Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy 05/2014; 132C:615-628. DOI:10.1016/j.saa.2014.04.182 · 2.13 Impact Factor