Warfarin overdose due to the possible effects of Lycium barbarum L.
ABSTRACT We reported an 80-year-old Chinese woman on chronic stable dose of warfarin who experienced two episodes of an elevated international normalized ratio (INR) after drinking herbal tea containing Lycium barbarum L. Our case illustrated the potential herbal-drug interaction between warfarin and L. barbarum L. in keeping with a previous case report. Enquiry about herbal intake may be a crucial part in the management of anticoagulation in this locality.
- SourceAvailable from: ruor.uottawa.ca
- [Show abstract] [Hide abstract]
ABSTRACT: Electrocrystallization of C-60 in organic solvents gave some single crystals of fulleride compounds, M(X)C(60)(solvent)(y) (M=PPN, Li, Na, K). The crystal of C-60(-.) anion radical salt of PPN+ (PPN = N[P(C6H5)(3)](2)) belongs to monoclinic system with space group of C2/c. C-60 is surrounded by bulky PPN cation and crystal solvent (monochlorobenzene) and has no short C...C contact between neighbouring C-60 anion radicals. Crystals of alkali-metal(Li, Na, K) C-60 compounds are isomorphic and have hexagonal unit cells. The four-probe d.c. resistivity measurements demonstrated the metallic nature of NaXC60(THF)(y)(x-0.4, y-2.2) with the room-temeperatur conductivity being 50 Scm(-1). Around 170 K the conductivity increased quite rapidly and reached as high as 1000 Scm(-1). This metal-metal transition is accompanied with the shortening of the lattice dimensions.Synthetic Metals 01/1994; 70(1-3). DOI:10.1109/STSM.1994.835554 · 2.22 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Lycium barbarum has been traditionally used in combination with several herbs for medicinal properties, but systematic modern clinical evaluation as a single herb has not been reported. To examine the systematic effects of L. barbarum on immune function, general well-being, and safety, we tested the effects of a standardized L. barbarum fruit juice (GoChi, FreeLife International, Phoenix, AZ, USA) at 120 mL/day, equivalent to at least 150 g of fresh fruit, the amount traditionally used, or placebo for 30 days in a randomized, double-blind, placebo-controlled clinical study in 60 older healthy adults (55-72 years old). The GoChi group showed a statistically significant increase in the number of lymphocytes and levels of interleukin-2 and immunoglobulin G compared to pre-intervention and the placebo group, whereas the number of CD4, CD8, and natural killer cells or levels of interleukin-4 and immunoglobulin A were not significantly altered. The placebo group showed no significant changes in any immune measures. Whereas the GoChi group showed a significant increase in general feelings of well-being, such as fatigue and sleep, and showed a tendency for increased short-term memory and focus between pre- and post-intervention, the placebo group showed no significant positive changes in these measures. No adverse reactions, abnormal symptoms, or changes in body weight, blood pressure, pulse, visual acuity, urine, stool, or blood biochemistry were seen in either group. In conclusion, daily consumption of GoChi significantly increased several immunological responses and subjective feelings of general well-being without any adverse reactions.Journal of medicinal food 10/2009; 12(5):1159-65. DOI:10.1089/jmf.2008.0300 · 1.70 Impact Factor