The Men's Eating and Living (MEAL) Study: A Cancer and Leukemia Group B Pilot Trial of Dietary Intervention for the Treatment of Prostate Cancer
ABSTRACT To evaluate the feasibility of implementing a diet-based intervention in men with prostate cancer.
Seventy-four men aged 50 to 80 years with biopsy-proven adenocarcinoma of the prostate were randomized to receive either telephone-based dietary counseling or standardized, written nutritional information. Telephone dietary counseling targets included increased intakes of vegetables (particularly cruciferous vegetables and tomato products), whole grains, and beans/legumes. Dietary intakes and plasma carotenoid levels were assessed at baseline and at 6 months' follow-up.
In the intervention arm, mean daily intakes of total vegetables, crucifers, tomato products, and beans/legumes increased by 76%, 143%, 292%, and 95%, respectively, whereas fat intake decreased by 12% (P = 0.02). In the control arm, there were no significant changes in mean intakes of total vegetables, tomato products, crucifers, beans/legumes, or fat. Similarly, in the intervention arm, mean plasma levels of alpha-carotene, beta-carotene, lutein, lycopene, and total carotenoids increased by 33%, 36%, 19%, 30%, and 26%, respectively (P <0.05). In the control arm, there were no significant changes in plasma levels of alpha- or beta-carotene, lutein, lycopene, or total carotenoids.
Telephone-based dietary counseling increases vegetable intake, decreases fat intake, and significantly increases plasma levels of potentially anticarcinogenic carotenoids in men with prostate cancer. These data support the feasibility of implementing clinical trials of dietary intervention in men with prostate cancer.
- SourceAvailable from: J. Kellogg Parsons
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- "Study design The MEAL Study is a randomized, phase III clinical trial. The intervention is a validated, telephone-based counseling program  . We are randomizing 464 patients on active surveillance to either the telephone-based counseling intervention or the control condition in which patients receive printed materials from the Prostate Cancer Foundation that recommend consumption of a healthy diet (Fig. 1). "
ABSTRACT: Diet may substantially alter prostate cancer initiation and progression. However, large-scale clinical trials of diet modification have yet to be performed for prostate cancer. The Men's Eating and Living (MEAL) Study (CALGB 70807 [Alliance]) is investigating the effect of increased vegetable consumption on clinical progression in men with localized prostate cancer.Contemporary Clinical Trials 05/2014; 38(2). DOI:10.1016/j.cct.2014.05.002 · 1.99 Impact Factor
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- "These dietary interventions were instrumental in conducting much needed clinical trials and achieved modest short-term diet changes but were comprehensive and labor-intensive and would be difficult to apply to larger patient populations. In addition, many were adapted from programs originally developed for women's diet intervention studies and were not gender savvy in their design and delivery (Demark-Wahnefried et al., 2007; Link et al., 2004; Parsons et al., 2008). "
ABSTRACT: Although healthy eating might enhance long-term survival, few men with prostate cancer make diet changes to advance their well-being. Men's typically poor diets and uninterest in self-health may impede nutrition interventions and diet change. Food choice behavior is complex involving many determinants, including gender, which can shape men's health practices, diets, and prostate cancer experiences. Developing men-centered prostate cancer nutrition interventions to engage men (and where appropriate their partners) in promoting healthy diets can afford health benefits. This article presents an overview and synthesis of current knowledge about men's food practices and provides an analysis of diet and diet change behaviors for men with prostate cancer. Masculinity and gender relations theory are discussed in the context of men's food practices, and suggestions for future applications to nutrition and prostate cancer research and diet interventions are made.American journal of men's health 03/2011; 5(2):177-87. DOI:10.1177/1557988310379152 · 1.15 Impact Factor