The Role of Botulinum Toxin Type A in the Radiation Fibrosis Syndrome: A Preliminary Report

Department of Neurology, Rehabilitation Medicine Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Archives of physical medicine and rehabilitation (Impact Factor: 2.57). 04/2008; 89(3):417-21. DOI: 10.1016/j.apmr.2007.11.022
Source: PubMed


To describe the use of botulinum toxin type A (BTX-A) in radiation fibrosis syndrome (RFS).
Retrospective case series.
A large tertiary care cancer center.
Twenty-three consecutive patients treated for sequelae of RFS with BTX-A.
Not applicable.
A description of the components of RFS thought to benefit from BTX-A injections and the patient's self-report of benefit from those injections.
The sequelae of RFS for which BTX-A injection was thought to be indicated include radiation-induced cervical dystonia in 18 (78%), trigeminal nerve or cervical plexus neuralgia in 10 (43%), trismus in 7 (30%), migraine in 3 (13%), and thoracic pain in 1 (4%) patient. Most (87%) patients self-reported benefit from the injections.
Initial clinical experience with the use of BTX-A as adjunctive treatment for select neuromuscular and musculoskeletal complications of RFS in a variety of cancer patients has been encouraging. Well-designed prospective studies are needed to clarify the potential beneficial role of BTX-A in specific sequelae of RFS.

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