Article

Vitamin D status in gastrointestinal and liver disease

Division of Gastroenterology and Nutrition, Department of Medicine, and General Clinical Research Center, Children's Hospital Boston, Boston, Massachusetts, USA.
Current opinion in gastroenterology (Impact Factor: 3.66). 04/2008; 24(2):176-83. DOI: 10.1097/MOG.0b013e3282f4d2f3
Source: PubMed

ABSTRACT The purpose of this review is to report on the vitamin D status and its relationship with bone health in individuals with gastrointestinal and liver disorders. In addition, recommendations regarding replacement and maintenance of optimal vitamin D stores, as well as the state of knowledge regarding its effect on the disease through its actions on the immune system, will be reviewed.
The scientific community has revised upward the serum levels of vitamin D considered optimal, and doses of vitamin D much larger than those currently recommended may be needed to maintain these levels, especially in individuals with gastrointestinal and liver disorders. The relationship between vitamin D and bone health in this population is controversial. The role of vitamin D in the regulation of the immune system continues to be elucidated.
Hypovitaminosis D is prevalent among individuals with gastrointestinal and liver disease. Although replacement and supplementation guidelines have not been well defined, practitioners should aim for a serum 25-hydroxyvitamin D level of at least 32 ng/ml. The contribution of vitamin D to the bone health of these individuals and its role in altering disease course through its actions on the immune system remain to be elucidated.

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    • "Thus, it is not surprising that VDD is a common observation in patients with liver disease (Nair, 2010; Stokes et al., 2013). The association between vitamin D status and liver diseases is a crucial one; low vitamin D may indicate liver dysfunction and VDD might contribute to liver damage through increased inflammation and fibrosis (Bikle, 2007; Bouillon et al., 2008; Pappa et al., 2008; Petta et al., 2010). Putz-Bankuti et al. (2012) reported a significant association between vitamin D level and the degree of liver dysfunction. "
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