Article

Chromosomal aberrations in a case of synchronous extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type and bronchogenic adenocarcinoma.

Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, UAS.
Applied immunohistochemistry & molecular morphology: AIMM / official publication of the Society for Applied Immunohistochemistry (impact factor: 1.63). 06/2008; 16(3):296-300. DOI:10.1097/PAI.0b013e318123fdea
Source: PubMed

ABSTRACT We present the chromosomal aberrations in a case of synchronous extranodal marginal zone B-cell lymphoma and bronchogenic adenocarcinoma with bronchioloalveolar features. Using fluorescence in situ hybridization, we identified deletion of the immunoglobulin heavy chain gene in the lymphomatous component, but not the carcinomatous component. The presence of differing genetic compositions suggests a biclonal environment composed of 2 distinct neoplastic processes.

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Keywords

2 distinct neoplastic processes
 
carcinomatous component
 
fluorescence
 
genetic compositions
 
immunoglobulin heavy chain gene
 
lymphomatous component
 
synchronous extranodal marginal zone B-cell lymphoma