Article

In vitro activity of daptomycin against multidrug-resistant Staphylococcus aureus and S. aureus with known virulence factors, including community-acquired methicillin-resistant isolates.

Cubist Pharmaceuticals Inc., Lexington, MA 02421, USA.
Diagnostic Microbiology and Infectious Disease (impact factor: 2.53). 08/2008; 61(3):339-42. DOI:10.1016/j.diagmicrobio.2008.01.012 pp.339-42
Source: PubMed

ABSTRACT The in vitro activity of daptomycin was evaluated against 360 multidrug-resistant Staphylococcus aureus isolates (including hospital-acquired isolates) and multidrug-susceptible community-acquired methicillin-resistant S. aureus with known virulence genes. All isolates were inhibited at <or=1 microg/mL, suggesting that daptomycin has excellent activity against both hospital-acquired and community-acquired S. aureus isolates.

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Keywords

360 multidrug-resistant Staphylococcus aureus
 
multidrug-susceptible community-acquired methicillin-resistant S. aureus
 
virulence genes
 
vitro activity