Article

Nodal melanocytic nevus with balloon-cell change (nodal balloon-cell nevus)

Dermatopathology Section, Pigmented Skin Lesions, S. M. Annunziata Hospital, Florence, Italy.
Journal of Cutaneous Pathology (Impact Factor: 1.56). 08/2008; 35(7):672-6. DOI: 10.1111/j.1600-0560.2007.00860.x
Source: PubMed

ABSTRACT Most nodal nevi are intracapsular and present the morphology of conventional nevi; less frequently, they show the appearance of common and cellular blue nevi. We report a case of an nodal capsular, trabecular and intraparenchymal melanocytic nevus with balloon-cell change in a patient with a malignant melanoma which arose in a pre-existing cutaneous giant congenital nevus, showing balloon-cell degeneration.

0 Followers
 · 
91 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: Cutaneous melanoma can produce a wide variety of unusual morphological appearances, sometimes mimicking other tumors. We report on 4 cases of melanoma with carcinoid-like features, namely, arrangement of neoplastic cells in trabecules, ribbons, pseudorosettes, rosettes, and/or small round islands. A total of 10 biopsies from 4 patients were available for a histopathological study comprising congenital nevus, a nodule that had developed in this nevus and its persistence/recurrence, 3 primary cutaneous lesions, 3 metastases, and a recurrent/persistent lesion. In 7 of these 10 lesions, the most characteristic finding was a distinctive arrangement of the neoplastic cells as trabecules, ribbons, pseudorosettes, rosettes, or small round insular islands, thus closely resembling cell arrangement in carcinoids of various organs. All these tumors were positive for melanocytic markers. No neuroendocrine differentiation was demonstrated immunohistochemically. We conclude that the carcinoid-like pattern in melanoma, namely, the pattern in which neoplastic cells are arranged in trabecules, ribbons, cords, rosettes, pseudorosettes, and small round insular nests resembling those in carcinoids, is a distinctive pattern, which may rarely occur in primary cutaneous melanoma, its recurrence or metastasis, or in a melanoma associated with a large congenital nevus. This morphological type of melanoma may produce a serious diagnostic pitfall, but despite a confusing microscopic appearance, these tumors seem to demonstrate a conventional immunohistochemical profile.
    The American Journal of dermatopathology 09/2009; 31(6):542-50. DOI:10.1097/DAD.0b013e3181a8525a
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Eccrine poroma is a benign neoplasm that can mimick a malignant neoplasm dermoscopically. The characteristic vascular pattern of this tumor has not been established. To evaluate dermoscopic features of non-pigmented eccrine poroma in Mexican patients. We retrospectively studied histologically proven cases of eccrine poroma from three Mexican hospitals analyzed by four dermoscopists. Thirteen cases were studied. A polymorphous vascular pattern was found in most cases. Four presented with irregular linear and branched vessels with semi-elliptical, or semicircular endings ("chalice-form" and "cherry-blossoms" vessels). Structureless pink-white areas were the most common other dermoscopic finding. "Chalice-form" and "cherry-blossom" vessels have not been reported in other benign or malignant neoplasms and can be a useful clue to the diagnosis of non-pigmented eccrine poroma. Due to the variability of dermoscopic patterns of eccrine poroma further studies are required to establish the specificity of our findings.
    01/2013; 3(1):25-8. DOI:10.5826/dpc.0301a07
  • [Show abstract] [Hide abstract]
    ABSTRACT: Histopathologic differentiation of nevus cell aggregates and metastatic melanoma in lymph nodes is challenging. Patients with melanoma who had undergone sentinel lymph node (SLN) biopsy were evaluated using univariate and multivariate analyses as well as Kaplan-Meier statistics. Of the 651 patients, 50 (7.7%) had a nodal nevus in the SLN. In the logistic regression model, primary melanoma on the lower extremities proved to be the strongest independent negative predictor of nodal nevi with an odds ratio of 0.11 (95% confidence interval, 0.034-0.36; P = .0002). Overall 5-year survival (P = .17) and 5-year disease-free survival (P = .45) of patients with nodal nevi did not significantly differ from that of patients with negative SLNs. The frequency and anatomic localization of nodal nevi observed in the present study are in line with previous studies. Our 5-year survival data clearly demonstrate that nevus cell aggregates in lymph nodes have to be considered a benign condition even though it occurs in patients with melanoma. This study provides an indirect proof of validity and accuracy of current histopathologic methods for differentiation between nodal nevi and melanoma metastasis.
    American Journal of Clinical Pathology 05/2013; 139(5):566-73. DOI:10.1309/AJCPG83CMAVFBWLC