Article

Nodal melanocytic nevus with balloon-cell change (nodal balloon-cell nevus).

Dermatopathology Section, Pigmented Skin Lesions, S. M. Annunziata Hospital, Florence, Italy.
Journal of Cutaneous Pathology (Impact Factor: 1.56). 08/2008; 35(7):672-6. DOI: 10.1111/j.1600-0560.2007.00860.x
Source: PubMed

ABSTRACT Most nodal nevi are intracapsular and present the morphology of conventional nevi; less frequently, they show the appearance of common and cellular blue nevi. We report a case of an nodal capsular, trabecular and intraparenchymal melanocytic nevus with balloon-cell change in a patient with a malignant melanoma which arose in a pre-existing cutaneous giant congenital nevus, showing balloon-cell degeneration.

0 Bookmarks
 · 
81 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: Histopathologic differentiation of nevus cell aggregates and metastatic melanoma in lymph nodes is challenging. Patients with melanoma who had undergone sentinel lymph node (SLN) biopsy were evaluated using univariate and multivariate analyses as well as Kaplan-Meier statistics. Of the 651 patients, 50 (7.7%) had a nodal nevus in the SLN. In the logistic regression model, primary melanoma on the lower extremities proved to be the strongest independent negative predictor of nodal nevi with an odds ratio of 0.11 (95% confidence interval, 0.034-0.36; P = .0002). Overall 5-year survival (P = .17) and 5-year disease-free survival (P = .45) of patients with nodal nevi did not significantly differ from that of patients with negative SLNs. The frequency and anatomic localization of nodal nevi observed in the present study are in line with previous studies. Our 5-year survival data clearly demonstrate that nevus cell aggregates in lymph nodes have to be considered a benign condition even though it occurs in patients with melanoma. This study provides an indirect proof of validity and accuracy of current histopathologic methods for differentiation between nodal nevi and melanoma metastasis.
    American Journal of Clinical Pathology 05/2013; 139(5):566-73. · 2.88 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Eccrine poroma is a benign neoplasm that can mimick a malignant neoplasm dermoscopically. The characteristic vascular pattern of this tumor has not been established. To evaluate dermoscopic features of non-pigmented eccrine poroma in Mexican patients. We retrospectively studied histologically proven cases of eccrine poroma from three Mexican hospitals analyzed by four dermoscopists. Thirteen cases were studied. A polymorphous vascular pattern was found in most cases. Four presented with irregular linear and branched vessels with semi-elliptical, or semicircular endings ("chalice-form" and "cherry-blossoms" vessels). Structureless pink-white areas were the most common other dermoscopic finding. "Chalice-form" and "cherry-blossom" vessels have not been reported in other benign or malignant neoplasms and can be a useful clue to the diagnosis of non-pigmented eccrine poroma. Due to the variability of dermoscopic patterns of eccrine poroma further studies are required to establish the specificity of our findings.
    Dermatology practical & conceptual. 01/2013; 3(1):25-8.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A case of balloon cell melanoma encountered in a primary care skin cancer practice in Melbourne, Australia is presented. The presenting lesion was 6 mm in diameter, ulcerated, non-pigmented and without any algorithmic clues to melanoma. However the presence of terminal hairs caused the clinician to suspect that it was melanocytic. The lesion was reported as a balloon cell melanoma, Clark level 4, Breslow thickness 2 mm with a mitotic index of 4 per square mm. This is an extremely rare melanoma subtype. Author DW has encountered only two cases in a career involving in excess of one million signed out dermatopathology reports. A search of the literature has not discovered any previously published dermatoscopy images of a balloon cell melanoma.
    Dermatology practical & conceptual. 07/2013; 3(3):25-29.