Autoimmune disease in individuals and close family members and susceptibility to non-Hodgkin's lymphoma

Danish Cancer Society, Copenhagen, Denmark.
Arthritis & Rheumatology (Impact Factor: 7.76). 03/2008; 58(3):657-66. DOI: 10.1002/art.23267
Source: PubMed


Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Sjögren's syndrome have been consistently associated with an increased risk of non-Hodgkin's lymphoma (NHL). This study was initiated to evaluate the risks of NHL associated with a personal or family history of a wide range of autoimmune diseases.
A population-based case-control study was conducted that included 24,728 NHL patients in Denmark (years 1977-1997) and Sweden (years 1964-1998) and 55,632 controls. Using univariate logistic and hierarchical regression models, we determined odds ratios (ORs) of NHL associated with a personal history of hospital-diagnosed autoimmune conditions. Risks of NHL associated with a family history of the same autoimmune conditions were assessed by similar regression analyses that included 25,941 NHL patients and 58,551 controls.
A personal history of systemic autoimmune diseases (RA, SLE, Sjögren's syndrome, systemic sclerosis) was clearly linked with NHL risk, both for individual conditions (hierarchical odds ratios [OR(h)] ranged from 1.6 to 5.4) and as a group (OR(h) 2.64 [95% confidence interval (95% CI) 1.72-4.07]). In contrast, a family history of systemic autoimmune diseases was modestly and nonsignificantly associated with NHL (OR(h) 1.31 [95% CI 0.85-2.03]). An increased risk of NHL was found for a personal history of 5 nonsystemic autoimmune conditions (autoimmune hemolytic anemia, Hashimoto thyroiditis, Crohn's disease, psoriasis, and sarcoidosis) (OR(h) ranged from 1.5 to 2.6) of 27 conditions examined.
Overall, our results demonstrate a strong relationship of personal history of systemic autoimmune diseases with NHL risk and suggest that shared susceptibility may explain a very small fraction of this increase, at best. Positive associations were found for a personal history of some, though far from all, nonsystemic autoimmune conditions.

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Available from: Ruth Pfeiffer, Dec 22, 2014
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    • "Two previous studies failed to confirm the association between sarcoidosis and lymphoma (15,16). Furthermore, in an attempt to quantify the association between non-HLs (NHLs) and various autoimmune and chronic inflammatory disorders, Mellemkjaer et al (17) conducted an analysis on >25,000 patients with sarcoidosis that were obtained from the Swedish and Danish Cancer Registries (14). A notable increase in the risk of NHL was observed in patients with a previous history of sarcoidosis (odds ratio, 1.9). "
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    ABSTRACT: The simultaneous presence of hematological malignancies and sarcoidosis, defined as sarcoidosis-lymphoma syndrome, has been reported in 79 patients in the literature to date. The majority of these patients were affected by sarcoidosis and developed non-Hodgkin lymphoma or acute leukemia after 1-2 years; however, in <20 cases the malignancy developed first. This report presents the case of an 83-year-old male with a clinical history of Helicobacter pylori-positive gastric mucosa-associated lymphoid tissue lymphoma. The patient developed sarcoidosis 10 years after the first diagnosis, which caused the diagnostic work-up and differential diagnosis between a lymphoma relapse and de novo sarcoidosis to be challenging.
    Oncology letters 09/2014; 8(3):1299-1301. DOI:10.3892/ol.2014.2241 · 1.55 Impact Factor
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    • "A statistically significant increase in risk of HL among patients with a family history of sarcoidosis or ulcerative colitis has been reported, but no association with a family history of other autoimmune conditions has been demonstrated (Landgren et al, 2006). Finally, an association between the risk of lymphoma development and a family history of a wide range of autoimmune diseases has not been detected in a population-based case-control study on 24,728 NHL patients (Mellemkjaer et al, 2008). Likewise, an increased risk of lymphoma occurrence among the first-degree relatives of RA patients has not been proven (Ekstrom et al, 2003). "

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