Article

The biochemistry of heme biosynthesis

Institute of Microbiology, Technical University of Braunschweig, Spielmannstr. 7, D-38106 Braunschweig, Germany.
Archives of Biochemistry and Biophysics (Impact Factor: 3.04). 07/2008; 474(2):238-51. DOI: 10.1016/j.abb.2008.02.015
Source: PubMed

ABSTRACT Heme is an integral part of proteins involved in multiple electron transport chains for energy recovery found in almost all forms of life. Moreover, heme is a cofactor of enzymes including catalases, peroxidases, cytochromes of the P(450) class and part of sensor molecules. Here the step-by-step biosynthesis of heme including involved enzymes, their mechanisms and detrimental health consequences caused by their failure are described. Unusual and challenging biochemistry including tRNA-dependent reactions, radical SAM enzymes and substrate derived cofactors are reported.

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    • "2.—Schematic representation of the tetrapyrrole biosynthesis pathway. Based on information from Martens et al. (2002), McGoldrick et al. (2005), Heinemann et al. (2008), Storbeck et al. (2010) and Bali et al. (2011) "
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