Article

Superoxidase dismutase (SOD) topical use in oncologic patients: treatment of acute cutaneous toxicity secondary to radiotherapy.

Departamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain.
Clinical and Translational Oncology (Impact Factor: 1.6). 04/2008; 10(3):163-7. DOI: 10.1007/s12094-008-0174-0
Source: PubMed

ABSTRACT The objective of this study is to evaluate the efficiency of SOD applied topically in oncologic patients affected by acute radiodermatitis.
This study includes 57 patients who showed a dermatitis grade 2 or superior; they were administered SOD ointment b.i.d. (40 mg, weekly) and follow-up continued for 12 weeks.
At the end of radiotherapy, 77.1% of the patients ameliorated completely or partially, and at the end of the 12-week period 100% of patients were free of toxicity. No acute toxicity relapses were reported. Response time reduced during radiotherapy, as well as the treatment time at the end of it.
The employment of SOD topically is efficient in the treatment of radiodermatitis, which is an acute side effect of radiotherapy.

1 Follower
 · 
88 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: Dyes have a long history and constitute an important component in our daily lives. The dye industry began by using natural plant and insect sources, and then rapidly turned to synthetic manufacturing processes. Unfortunately, several of the synthetic dyes, especially azo dyes, have been found to be toxic and mutagenic, and are banned throughout the world. However, because of their low cost and other desirable properties, the use and manufacture of azo dyes continues even today. Removal and treatment of azo dyes from wastewater presents a very special challenge. Since azo dyes are recalcitrant to the conventional aerobic biological treatment, and physical/chemical treatment processes are neither ecofriendly nor economical, innovative remediation approaches need to be explored. In the current scenario, a combination of biological and advanced oxidation processes seem to be the most desired solution. Moreover, mechanistic studies of the pathways and enzymes involved in dye degradation and detoxification need to be undertaken for process optimization. This paper critically and comprehensively reviews recent research advances and the knowledge-base of the previously mentioned areas, including history and chemistry of dyes, mechanistic studies on their persistence, ecotoxicity, and carcinogenicity, and potential remediation methods. Particular emphasis has been given towards critical evaluation of the existing dye wastewater treatment methods and their full-scale applications; based on which recommendations have been made for future developments of the treatment technologies and their assessment methods. In the Authors' opinion, a more holistic and large-scale approach is required to tackle the chronic problem of dye pollution.
    Environmental Reviews 12/2011; 19:350-370. DOI:10.1139/a11-018 · 2.36 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Radiation-induced skin damage is one of the most common complications of radiotherapy. In order to combat these side effects, patients often turn to alternative therapies, which often include antioxidants. Antioxidants such as those in the polyphenol chemical class, xanthine derivatives, tocepherol, sucralfate, and ascorbate have been studied for their use in either preventing or treating radiotherapy-induced skin damage. Apart from their known role as free radical scavengers, some of these antioxidants appear to alter cytokine release affecting cutaneous and systemic changes. We review the role of antioxidants in treating and preventing radiation-induced skin damage as well as the possible complications of using such therapy.
    Integrative Cancer Therapies 05/2013; 13(1). DOI:10.1177/1534735413490235 · 2.01 Impact Factor
  • Source
    Edited by Jose M. Soriano y Alegría Montoro, 12/2013; Consejo de Seguridad Nuclear.