Article

[Antigenic and genetic study of influenza virus circulated in China in 2006].

Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, State Key Laboratory for Infectious Disease Control and Prevention, China CDC. Beijing 100052, China.
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 01/2008; 21(4):304-6. pp.304-6
Source: PubMed

ABSTRACT To analyse seasonal influenza epidemic situation in 2006, and to analyse the genetic and antigenic characteristics of viral hemagglutinin (HA) gene.
The single-way hemagglutination inhibition (HI) tests were used to test the antigenic characteristics of these viruses from influenza surveillance network, and the HA1 genes were sequenced based on the antigenic test results according to different isolation times and sites.
The influenza virus types A and B co-circulated in 2006. influenza A H1N1 subtype and Victoria-like B influenza circulated preponderantly during this epidemic season. The HA1 gene sequence of H1N1 viruses showed that 192, 193, 196, 198 positions (located at antigenic site B) have an amino acid substitute, compared with the last circulating strain A/Hubeihongshan/53/2005(H1N1). Two amino acid changes at 142 and 144 positions compared with A/Yunnan/1145/2005 (H3N2). There was no change in influenza B viruses either Victoria-like B or Yamagata-like B virus, i.e . antigenic characteristics is analogous to B/shenzhen/155/2005 and B/tianjin/144/2005, respectively.
The H1N1 and H3N2 influenza viruses had changing antigenic and genetic characteristics in 2006. Influenza virus types B did not change in 2006.

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Keywords

198 positions
 
amino acid changes
 
amino acid substitute
 
analyse seasonal influenza epidemic situation
 
antigenic characteristics
 
antigenic site B
 
antigenic test results
 
different isolation times
 
genetic characteristics
 
H1N1 subtype
 
H1N1 viruses
 
H3N2 influenza viruses
 
influenza B viruses
 
influenza surveillance network
 
influenza virus types
 
Influenza virus types B
 
single-way hemagglutination inhibition
 
Victoria-like B
 
Victoria-like B influenza
 
viral hemagglutinin