Article

Confocal blue reflectance imaging in type 2 idiopathic macular telangiectasia.

Department of Ophthalmology, University of Bonn, Bonn, Germany.
Investigative Ophthalmology &amp Visual Science (impact factor: 3.6). 04/2008; 49(3):1172-7. DOI:10.1167/iovs.07-0636 pp.1172-7
Source: PubMed

ABSTRACT To report the characteristics of confocal blue reflectance imaging in type 2 idiopathic macular telangiectasia (type 2 IMT).
In a prospective observational cross-sectional study, both eyes of 33 patients with type 2 IMT were examined by means of fundus biomicroscopy, fundus photography, fluorescein angiography, and optical coherence tomography (OCT). Confocal blue reflectance (CBR) imaging was performed using a confocal scanning laser ophthalmoscope (HRA2; Heidelberg Engineering, Heidelberg, Germany). To compare the results derived from different imaging modalities, an analysis was performed using image analysis software (Heidelberg Eye Explorer; Heidelberg Engineering).
CBR imaging revealed a parafoveal area of increased reflectance that was slightly larger than the area of hyperfluorescence in late-phase fluorescein angiography. The area usually encompassed an oval parafoveal area, but sectors could be spared. A parafoveal area of increased CBR was detected in 98% of eyes that showed angiographic evidence for type 2 IMT.
CBR imaging is a new, noninvasive, and sensitive method that may contribute to differentiate type 2 IMT from other diseases. Abnormalities of macular pigment distribution and Müller cell pathology may contribute to the phenomenon of increased CBR and thus the pathophysiology of type 2 IMT.

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Keywords

CBR imaging
 
Confocal blue reflectance
 
confocal blue reflectance imaging
 
confocal scanning laser ophthalmoscope
 
different imaging modalities
 
differentiate type 2 IMT
 
eyes
 
fluorescein angiography
 
fundus photography
 
Heidelberg Engineering
 
Heidelberg Eye Explorer
 
hyperfluorescence
 
late-phase fluorescein angiography
 
Müller cell pathology
 
noninvasive
 
pathophysiology
 
prospective observational cross-sectional study
 
sensitive method
 
type 2 idiopathic macular telangiectasia
 
type 2 IMT