Harry L. Goldsmith, Ph.d.

University of Pennsylvania, Philadelphia, PA, USA, .
Annals of Biomedical Engineering (Impact Factor: 3.23). 05/2008; 36(4):523-6. DOI: 10.1007/s10439-008-9479-y
Source: PubMed


In honor of Dr. Harry L. Goldsmith's 75th birthday, we present a collection of articles from his collaborators and colleagues to commemorate Harry's outstanding contributions to the field of Biorheology. On any particular day, bioengineers around the world may find themselves fortunate enough to peer through a microscope to observe molecular or cellular level phenomena manifested before their eyes. Such observations of single molecule mechanics or blood flows or cellular deformation remind us of the power of clever experimental design and rigorous theoretical constructs as well as the complex beauty of dynamical systems in nature. In this spirit, the investigations reported in this issue of the Annals entitled Cellular Biorheology and Biomechanics have followed down many of the research paths pioneered by Dr. Harry Goldsmith.

Download full-text


Available from: Michael B Lawrence, Aug 05, 2014
17 Reads
  • [Show abstract] [Hide abstract]
    ABSTRACT: Fluid mechanical factors are probably involved in the localization of atherosclerotic lesions and the deposition of platelet thrombi at arterial branches where secondary flows and vortices develop. Hence, we have studied the flow patterns in glass models of 3 mm diameter right angled T-junctions with square or rounded corners. With flow entering through the main tube, cine films of the paths of microspheres in dilute suspensions were taken at inflow Reynolds number Re(o) from 15 to 420 and flow ratios Q1/Q2 main: side tube from 0.05 to 4.0. In the square T-junction, paired vortices symmetrical about the common median plane formed at the entrances of the main and side daughter tubes over a wide range of Re(o) and Q1/Q2. Particles spiralled in open streamlines through the large main vortex; some then crossed above or below the mainstream to the side tube and through the side vortex, downstream of which there was a double helical flow. At high Q1/Q2, only the side vortex was present. At Q1/Q2<0.1 and Re(o)>100, a third vortex formed downstream of the main vortex. In the rounded T-junction, the main vortex was formed at a lower, and the side vortex at a higher Re(o) than in the square T-junction. When flow entered through the side tube, paired connected vortices were also formed, but only when one daughter tube was severely occluded.
    Biorheology 02/1979; 16(3):231-48. · 1.18 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: WE have extended recent observations of the radial movements of single rigid1,2 and deformable3 spheres suspended in Newtonian liquids flowing through straight circular tubes to include other particle shapes and visco-elastic fluids.
    Nature 09/1963; 200(4781):159-160. DOI:10.1038/200159a0 · 41.46 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: A general method of calculating forces, torques, and translational and rotational velocities of rigid, neutral, equal-sized spheres in a viscous fluid undergoing uniform shear flows is presented. The method is based on the matrix formulation of the hydrodynamic resistances by Brenner and O'Neill, and it is illustrated for simple shear and planar and axisymmetric extensional flows, for which the trajectories of pairs of sphere centers are calculated. It is shown that, in simple shear, trajectories are either open or closed; in extensional flows, all trajectories must be open. This has interesting implications in the dispersion of aggregates by shear. Although the translational and rotational behavior of interacting spheres is characterized by the type of flow, the behavior of the spheres in each flow is calculable from flow-independent quantities. Special emphasis is placed on the collision behavior of doublets. Initially separate spheres can never touch, but they can come into very close proximity, especially during equatorial encounters. In simple shear, translating spheres rotate about their own axes, which, in a doublet, causes one sphere to roll relative to the other except when they touch or are rigidly connected. The rotations of free and connected doublets and dumbbells are related to those of prolate spheroids.
    Journal of Colloid and Interface Science 08/1977; 61(1):21-43. DOI:10.1016/0021-9797(77)90413-1 · 3.37 Impact Factor
Show more