Correlation between voxel based morphometry and manual volumetry in magnetic resonance images of the human brain.

Divisão de Psiquiatria, Faculdade de Medicina de Ribeirão Preto, Hospital das Clínicas, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Anais da Academia Brasileira de Ciências (Impact Factor: 0.85). 04/2008; 80(1):149-56. DOI: 10.1590/S0001-37652008000100010
Source: PubMed

ABSTRACT This is a comparative study between manual volumetry (MV) and voxel based morphometry (VBM) as methods of evaluating the volume of brain structures in magnetic resonance images. The volumes of the hippocampus and the amygdala of 16 panic disorder patients and 16 healthy controls measured through MV were correlated with the volumes of gray matter estimated by optimized modulated VBM. The chosen structures are composed almost exclusively of gray matter. Using a 4 mm Gaussian filter, statistically significant clusters were found bilaterally in the hippocampus and in the right amygdala in the statistical parametric map correlating with the respective manual volume. With the conventional 12 mm filter,a significant correlation was found only for the right hippocampus. Therefore, narrow filters increase the sensitivity of the correlation procedure, especially when small brain structures are analyzed. The two techniques seem to consistently measure structural volume.

  • [Show abstract] [Hide abstract]
    ABSTRACT: Protected areas established on private land are an important tool for biodiversity conservation, complementing the government efforts to protect nature. Encouraging the establishment of Private Reserves of Natural Heritage (RPPN, as its portuguese acronysm) in areas of conservation priority is considered strategic for the implemention of the Central Corridor of Atlantic Forest. This paper shows a NGO' experiment to increase the quantity and space of protected areas under RPPN in the World Natural Heritage Site of Southern Bahia.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Multiresolution analysis is an established part of the human vision system. It builds different representations of an image with a spatial resolution adapted to the size of objects of interest and to its level of relevance. Multiresolution analysis is an efficient tool for image segmentation. It allows the processing of global features as well as local features in a corresponding proper scale. Furthermore, it simplifies the segmentation process, accelerates the computation, and improves the results. In this work we propose a segmentation algorithm that is based on the multiresolution analysis for the magnetic resonance images of the human brain. It has been evaluated against known algorithm from the literature. The image subject to segmentation is preprocessed to be represented in a mosaic of different resolutions, based on the distribution of the information contained in the image. Then the conventional EM algorithm is applied for the segmentation.
    High Performance Computing & Simulation, 2009. HPCS '09. International Conference on; 07/2009
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: There have been several reports on the association between the Val(158)Met genetic polymorphism of the catechol-O-methyltransferase gene (COMT), as well as the serotonin transporter linked polymorphic region (5-HTTLPR) of the serotonin transporter gene (SLC6A4), and fronto-limbic region volumes, which have been suggested to underlie individual differences in emotion processing or susceptibility to emotional disorders. However, findings have been somewhat inconsistent. This study used diffeomorphic anatomic registration through exponentiated Lie algebra (DARTEL) whole-brain voxel-based morphometry (VBM) to study the genetic effects of COMT Val(158)Met and SLC6A4 5-HTTLPR, as well as their interaction, on the regional gray matter volumes of a sample of 91 healthy volunteers. An interaction of COMT Val(158)Met x SLC6A4 5-HTTLPR genotypes with gray matter volume was found in bilateral parahippocampal gyrus, amygdala, hippocampus, vermis of cerebellum and right putamen / insula. In particular, the gray matter volume in these regions was smaller in individuals who were both COMT-Met and 5-HTTLPR-S carriers, or both COMT-Val and 5-HTTLPR-L homozygotes, as compared to individuals with intermediate combinations of alleles. The interaction of COMT Val(158)Met and SLC6A4 5-HTTLPR adds to the understanding of individual differences in emotion processing.
    Social Cognitive and Affective Neuroscience 06/2013; · 5.04 Impact Factor


Available from
May 21, 2014