Article

Influence of cefoperazone and azithromycin on the pharmacokinetics of pazufloxacin in rats.

School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
European Journal of Drug Metabolism and Pharmacokinetics (impact factor: 0.36). 32(4):219-23.
Source: PubMed

ABSTRACT The effects of cefoperazone and azithromycin administered separately on the pharmacokinetics of pazufloxacin (PZFX) mesilate were investigated in rats. Animals were injected with cefoperazone at a high dose (180 mg/kg) or azithromycin at a dose of 45 mg/kg through the tail vein 10 min before intravenous (i.v.) administration of PZFX (45 mg/kg). Blood concentrations of PZFX were determined by HPLC. Parameters relating to the pharmacokinetic interaction between PZFX and cefoperazone or azithromycin were estimated by a two-compartmental model. The experimental results showed that the presence of azithromycin significantly delayed the t(1/2 beta) and mean residence time (MRT) of PZFX in the plasma. However, no significant changes between the control group and the cefoperazone-treated animals in the pharmacokinetic parameters of PZFX, such as t(1/2 beta), volume of distribution (Vd), area under the curve (AUC) and the clearance (Cl) were observed.

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Keywords

azithromycin
 
Blood concentrations
 
cefoperazone-treated animals
 
Cl
 
clearance
 
control group
 
experimental results
 
pharmacokinetic interaction
 
pharmacokinetic parameters
 
pharmacokinetics
 
PZFX
 
rats
 
residence time
 
significant changes
 
tail vein 10 min
 
two-compartmental model
 
Vd