Article

Statistical methods for evidence-based medicine: the diagnostic test. Part II.

Medical Statistics and Biometry Unit, Department of Biomedical Sciences and Biotechnologies, University of Brescia, Brescia, Italy.
Minerva anestesiologica (impact factor: 2.66). 04/2008; 74(9):481-8. pp.481-8
Source: PubMed

ABSTRACT Part II of this work addresses the use of likelihood ratios for the calculation of a positive predictive value (PPV) and a negative predictive value (NPV) for patient diagnosis. These two values are the most useful indices in the application of a diagnostic test in order to make a diagnosis for a patient. Furthermore, the relevance of sample size is also addressed by providing background theory and pertinent tables. These basic topics for assessing the validity of a diagnostic test and for performing appropriate and valid case vs control studies are explained in a simple way for a clinical audience with a working example.

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Keywords

appropriate
 
background theory
 
basic topics
 
negative predictive value
 
NPV
 
patient diagnosis
 
pertinent tables
 
positive predictive value
 
sample size
 
simple way
 
two values
 
useful indices
 
work addresses
 
working example
 

P Antonelli