Gastric electrical stimulation for children with intractable nausea and gastroparesis

Division of Pediatric Surgery, Department of Surgery, University of Mississippi Medical Center, Jackson, MS 32916, USA.
Journal of Pediatric Surgery (Impact Factor: 1.39). 04/2008; 43(3):437-42. DOI: 10.1016/j.jpedsurg.2007.10.005
Source: PubMed


Gastric electrical stimulation (GES) has been performed in adults as a treatment of refractory nausea and vomiting in patients who have failed medical treatment, but has not been used in children.
Nine patients with chronic nausea and vomiting with a mean age of 14 years were evaluated for temporary GES. All 9 patients subsequently underwent placement of a temporary followed by permanent GES device. Symptoms were recorded at baseline, after temporary GES, and then after permanent GES using a Likert scale for gastroparesis. Statistical analysis was performed using a paired Student's t test.
At baseline, all patients were symptomatic and most had delayed solid gastric emptying. As a group, there was a significant improvement in combined symptoms score (P = .04), nausea (P = .039), and vomiting (P = .0016). Gastric emptying and electrogastrogram values did not change significantly. Follow-up ranged from 8 to 42 months, with 7 of the 9 patients reporting sustained improvement in symptoms and improved quality of life.
Gastric electrical stimulation can be successfully applied to adolescents with intractable nausea and gastroparesis symptoms who fail medical therapy. There is a significant improvement in symptoms over a prolonged period, and there are no adverse effects of the GES. Long-term efficacy of this therapy in children needs to be established.

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Available from: Thomas L Abell, Mar 19, 2014

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Article: Gastric electrical stimulation for children with intractable nausea and gastroparesis

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    • "This intervention is based on the laparoscopic implantation of two electrodes - connected to a pacemaker - into the seromuscular layer of the stomach. Two studies in children with gastroparesis demonstrated that gastric stimulation alleviated their symptoms and improved quality of life [85,86]. Despite the promising results the long-term efficacy and safety of this modality need to be established. "
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