Effect of MBSR on immune function, quality of life, and coping in women newly diagnosed with early stage breast cancer. Brain, Behavior and Immunology, 22, 969-981

Niehoff School of Nursing, Loyola University of Chicago, Maguire Center, Room 2840, 2160 South First Avenue, Maywood, IL 60153, USA.
Brain Behavior and Immunity (Impact Factor: 5.89). 09/2008; 22(6):969-81. DOI: 10.1016/j.bbi.2008.01.012
Source: PubMed


This investigation used a non-randomized controlled design to evaluate the effect and feasibility of a mindfulness based stress reduction (MBSR) program on immune function, quality of life (QOL), and coping in women recently diagnosed with breast cancer. Early stage breast cancer patients, who did not receive chemotherapy, self-selected into an 8-week MBSR program or into an assessment only, control group. Outcomes were evaluated over time. The first assessment was at least 10 days after surgery and prior to adjuvant therapy, as well as before the MBSR start-up. Further assessments were mid-MBSR, at completion of MBSR, and at 4-week post-MBSR completion. Women with breast cancer enrolled in the control group (Non-MBSR) were assessed at similar times. At the first assessment (i.e., before MBSR start), reductions in peripheral blood mononuclear cell NK cell activity (NKCA) and IFN-gamma production with increases in IL-4, IL-6, and IL-10 production and plasma cortisol levels were observed for both the MBSR and Non-MBSR groups of breast cancer patients. Over time women in the MBSR group re-established their NKCA and cytokine production levels. In contrast, breast cancer patients in the Non-MBSR group exhibited continued reductions in NKCA and IFN-gamma production with increased IL-4, IL-6, and IL-10 production. Moreover, women enrolled in the MBSR program had reduced cortisol levels, improved QOL, and increased coping effectiveness compared to the Non-MBSR group. In summary, MBSR is a program that is feasible for women recently diagnosed with early stage breast cancer and the results provide preliminary evidence for beneficial effects of MBSR; on immune function, QOL, and coping.

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Available from: Ramón Angel Durazo-Arvizu, Jul 07, 2014
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    • "Significant effects for cytokine outcomes consist of greater production of stimulated or unstimulated TH 1 cytokines such as IL-2, IL-12, and IFN-␥ (Antoni et al., 2009; Cohen et al., 2011; Witek-Janusek et al., 2008) and decreases in TH 2 cytokines such as IL-4 and IL-10 or reductions in helper:suppressor ratios (Witek-Janusek et al., 2008). Reductions in cortisol or normalization of diurnal cortisol patterns have also been reported (Antoni et al., 2009; Carlson et al., 2013; Cruess et al., 2000; Phillips et al., 2008; Witek-Janusek et al., 2008). "
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    • "In fact, a number of studies have reported lower levels of pro-inflammatory markers (IL-6) [37]-[39] and stress hormones (specifically cortisol) among those who are more religious [40]-[44]. Furthermore, spiritual interventions have been shown to reduce the pro-/anti-inflammatory cytokine ratios [45] [46], reduce cortisol [47]-[51], and decrease catecholamine [52] [53] levels. "
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    Open Journal of Psychiatry 10/2014; 4(4):335-352. DOI:10.4236/ojpsych.2014.44040
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    • "While not specifically addressing PTG, previous research has found relationships between mindfulness as state, trait, and practice and the majority of PTG outcomes delineated by Tedeschi and Calhoun (2004). Mindfulness has been linked with spirituality (Carmody et al. 2008; Garland et al. 2007; Witek-Janusek et al. 2008), broadened perspectives/cognitive flexibility (Garland et al. 2010; Moore and Malinowski 2009), personal strength (Kurash and Schaul 2006; Niemiec 2012), improved relationships (Jones et al. 2011; Rothaupt and Morgan 2011; Witek-Janusek et al. 2008), as well as heighted appreciation of and satisfaction with life (Brown and Ryan 2003; Fredrickson et al. 2008; Geschwind et al. 2011). These findings suggest that individuals higher in trait mindfulness would likely experience greater PTG in the wake of adverse life events. "
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