Article

Association between GERD-related erosive esophagitis and obesity.

Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Journal of clinical gastroenterology (impact factor: 2.21). 08/2008; 42(6):672-5. DOI:10.1097/MCG.0b013e31806daf64 pp.672-5
Source: PubMed

ABSTRACT To date, many studies have reported on the association of obesity with gastroesophageal reflux disease (GERD), although none of these have been systematic. In light of this, we conducted this study to examine the association of obesity and GERD.
A total of 3363 patients underwent gastroscopy at Hanyang University Health Promotion Center. Among these patients, we prospectively examined patients who were diagnosed with GERD-related erosive esophagitis on endoscopy.
Multivariate analysis showed that the significant risk factors were waist-to-hip ratio (WHR), hiatal hernia, body mass index (BMI), and smoking. As compared with patients who had a WHR less than 0.8, the multivariate odds ratio for erosive esophagitis were 4.055 for a WHR more than 1.0 and 2.316 for a WHR of 0.8 to 1.0. As compared with patients who had a BMI of 20 to 22.5, the multivariate odds ratio for erosive esophagitis was 3.308 (95% confidence interval, 1.792 to 6.107) for a BMI greater than 30.
Obesity, especially abdominal obesity, was the significant risk factor for erosive esophagitis.

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Keywords

95% confidence interval
 
abdominal obesity
 
body mass index
 
endoscopy
 
erosive esophagitis
 
gastroscopy
 
GERD
 
GERD-related erosive esophagitis
 
Hanyang University Health Promotion Center
 
hiatal hernia
 
Multivariate analysis
 
multivariate odds ratio
 
obesity
 
patients
 
significant risk factor
 
significant risk factors
 

Hang Lak Lee