Article

Amyloid imaging in aged and young macaques with [11C]PIB and [18F]FDDNP.

Basic Research Division, The Medical and Pharmacological Research Center Foundation, Hakui, Japan.
Synapse (impact factor: 2.94). 07/2008; 62(6):472-5. DOI:10.1002/syn.20508
Source: PubMed

ABSTRACT [11C]PIB and [18F]FDDNP were examined on five aged and five young adult male rhesus macaques using positron emission tomography. Both tracers showed increased accumulation in the striatum, thalamus, cingulate and pons in the aged group. Compared to [11C]PIB, [18F]FDDNP showed higher accumulation in the cortical regions of aged animals as well as young animals. Although [18F]FDDNP may have possible usefulness for imaging, including other proteins, [11C]PIB may be better for amyloid imaging owing to lower non-specific binding.

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Keywords

amyloid imaging
 
cortical regions
 
imaging
 
lower non-specific binding
 
pons
 
positron emission tomography
 
proteins
 
striatum
 
young adult male rhesus macaques