Article

Mixture design applied to optimize a directly compressible powder produced via cospray drying.

Laboratory of Pharmaceutical Technology, Ghent University, Gent, Belgium.
Drug Development and Industrial Pharmacy (impact factor: 1.49). 04/2008; 34(3):248-57. DOI:10.1080/03639040701542143 pp.248-57
Source: PubMed

ABSTRACT Coprocessing via spray drying was applied to improve the compactability of acetaminophen and to select an optimal formulation. Four-component mixtures containing acetaminophen, mannitol, erythritol, and maltodextrin were produced by cospray drying. A D-optimal mixture design was constructed to evaluate the spray dried powder and tablet properties. An increasing mannitol and erythritol content improved powder flowability and density. However, a higher erythritol concentration in the spray dried powder mixture had a negative influence on tablet tensile strength and friability. A higher maltodextrin content increased tablet tensile strength and improved tablet friability, while disintegration time, average particle size, powder flowability, density, and hygroscopicity were negatively influenced.

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Keywords

average particle size
 
compactability
 
cospray drying
 
D-optimal mixture design
 
disintegration time
 
erythritol content
 
Four-component mixtures
 
friability
 
higher maltodextrin content
 
increasing mannitol
 
maltodextrin
 
mannitol
 
negative influence
 
optimal formulation
 
powder flowability
 
powder mixture
 
spray
 
spray drying
 
tablet friability
 
tablet properties